{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:24:50Z","timestamp":1785684290817,"version":"3.56.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T00:00:00Z","timestamp":1553040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Histopathological overlap between lupus erythematosus and certain types of cutaneous T cell lymphoma (<jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>) is well documented. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>123<jats:sup>+<\/jats:sup> plasmacytoid dendritic cells (<jats:styled-content style=\"fixed-case\">PDC<\/jats:styled-content>s) are typically increased in lupus erythematosus, but have not been well studied in <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>. We aimed to compare <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>123 immunostaining and histopathological features in these conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Skin biopsies of cutaneous lupus erythematosus (<jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content>,<jats:italic> n<\/jats:italic> = 18), lupus erythematosus panniculitis (<jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content>,<jats:italic> n<\/jats:italic> = 17), mycosis fungoides (<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>,<jats:italic> n<\/jats:italic> = 25) and subcutaneous panniculitis\u2010like T cell lymphoma (<jats:styled-content style=\"fixed-case\">SPTCL<\/jats:styled-content>,<jats:italic> n<\/jats:italic> = 9) were retrospectively reviewed and immunostained with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>123. Percentage, distribution and clustering of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>123<jats:sup>+<\/jats:sup> cells were compared between <jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> and between <jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SPTCL<\/jats:styled-content> using \u03c7<jats:sup>2<\/jats:sup> and two\u2010tailed <jats:italic>t<\/jats:italic>\u2010tests. A higher percentage of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>123<jats:sup>+<\/jats:sup> cells was observed in <jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content> than <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> (<jats:italic>P<\/jats:italic> &lt; 0.01), more frequently comprising \u226520% of the entire infiltrate (<jats:italic>P<\/jats:italic> &lt; 0.01) and forming clusters (<jats:italic>P<\/jats:italic> &lt; 0.01). Similarly, <jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content> showed a higher percentage of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>123<jats:sup>+<\/jats:sup> cells than <jats:styled-content style=\"fixed-case\">SPTCL<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.01), more frequently comprising \u226520% of the infiltrate (<jats:italic>P<\/jats:italic> = 0.04) and forming clusters (<jats:italic>P<\/jats:italic> = 0.01). Basal vacuolar change or dyskeratosis was observed in all <jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content> cases and in 48% cases of <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> cases (<jats:italic>P<\/jats:italic> = 0.05). Plasma cells were readily identified in 76% cases of <jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content> but in none of the <jats:styled-content style=\"fixed-case\">SPTCL<\/jats:styled-content> cases (<jats:italic>P<\/jats:italic> = 0.01). Adipocyte rimming by lymphocytes, hyaline fat necrosis and fibrinoid\/grungy necrosis did not significantly differ between <jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SPTCL<\/jats:styled-content>. Dermal mucin also failed to distinguish between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>123 immunostaining is helpful in differentiating <jats:styled-content style=\"fixed-case\">CLE<\/jats:styled-content> from <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content> from <jats:styled-content style=\"fixed-case\">SPTCL<\/jats:styled-content>, but should be interpreted in conjunction with clinicopathological features and other ancillary studies to ensure accurate diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13817","type":"journal-article","created":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T22:45:38Z","timestamp":1546296338000},"page":"908-916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Utility of <scp>CD<\/scp>123 immunohistochemistry in differentiating lupus erythematosus from cutaneous T cell lymphoma"],"prefix":"10.1111","volume":"74","author":[{"given":"Stephanie J T","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor MI USA"},{"name":"Department of Pathology University of Iowa Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie Y","family":"Tse","sequence":"additional","affiliation":[{"name":"Department of Pathology Tufts Medical Center Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0802-2883","authenticated-orcid":false,"given":"Paul W","family":"Harms","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor MI USA"},{"name":"Department of Dermatology University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra C","family":"Hristov","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor MI USA"},{"name":"Department of Dermatology University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0650-1266","authenticated-orcid":false,"given":"May P","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor MI USA"},{"name":"Department of Dermatology University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1985.tb01629.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01566.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000153121.57515.c6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00662.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00417527"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90430-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-198812000-00001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)80218-6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2007.02546.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000942"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199710000-00003"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.028005235.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2005.00331.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-005-0125-x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-087288"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000307"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2014-202849"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000596"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2016.11.009"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb05030.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200106000-00008"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)02784-1"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181a84f32"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61689-6"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh088"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2009.06.013"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01443.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2010.01587.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12105"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.01.892"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12416"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12654"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12725"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2011.01779.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00848.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.014"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001173"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1220"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-017-2107-1"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199512000-00009"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199407000-00001"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.13817","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.13817","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/his.13817","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.13817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T18:28:32Z","timestamp":1694370512000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.13817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,20]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/his.13817"],"URL":"https:\/\/doi.org\/10.1111\/his.13817","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,20]]},"assertion":[{"value":"2018-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}