{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:45:38Z","timestamp":1789940738953,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,14]],"date-time":"2019-04-14T00:00:00Z","timestamp":1555200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      The four\u2010tiered peritoneal regression grading score (\n                      <jats:styled-content style=\"fixed-case\">PRGS<\/jats:styled-content>\n                      ) assesses the response to chemotherapy in peritoneal metastasis (\n                      <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>\n                      ). The\n                      <jats:styled-content style=\"fixed-case\">PRGS<\/jats:styled-content>\n                      is used, for example, to assess the response to pressurised intraperitoneal aerosol chemotherapy (\n                      <jats:styled-content style=\"fixed-case\">PIPAC<\/jats:styled-content>\n                      ). However, the reproducibility of the\n                      <jats:styled-content style=\"fixed-case\">PRGS<\/jats:styled-content>\n                      is currently unknown. We aimed to evaluate the inter\u2010 and intraobserver variability of the\n                      <jats:styled-content style=\"fixed-case\">PRGS<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010three patients who underwent at least three\n                      <jats:styled-content style=\"fixed-case\">PIPAC<\/jats:styled-content>\n                      treatments as part of the\n                      <jats:styled-content style=\"fixed-case\">PIPAC<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">OPC<\/jats:styled-content>\n                      1 or\n                      <jats:styled-content style=\"fixed-case\">PIPAC<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">OPC<\/jats:styled-content>\n                      2 clinical trials at Odense University Hospital, Denmark, were included. Prior to each therapy cycle, peritoneal quadrant biopsies were obtained and three haematoxylin and eosin (H&amp;E)\u2010stained step sections were scanned and uploaded to a pseudonymised web library. For determining interobserver variability, eight pathologists assessed the\n                      <jats:styled-content style=\"fixed-case\">PRGS<\/jats:styled-content>\n                      for each quadrant biopsy, and Krippendorff's alpha and intraclass correlation coefficients (\n                      <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>\n                      s) were calculated. For determining intraobserver variability, three pathologists repeated their own assessments and Cohen's kappa and\n                      <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>\n                      s were calculated. A total of 331 peritoneal biopsies were analysed. Interobserver variability for\n                      <jats:styled-content style=\"fixed-case\">PRGS<\/jats:styled-content>\n                      of each biopsy and for the mean and maximum\n                      <jats:styled-content style=\"fixed-case\">PRGS<\/jats:styled-content>\n                      per biopsy set was moderate to good\/substantial. The intraobserver variability for\n                      <jats:styled-content style=\"fixed-case\">PRGS<\/jats:styled-content>\n                      of each biopsy and for the mean and maximum\n                      <jats:styled-content style=\"fixed-case\">PRGS<\/jats:styled-content>\n                      per biopsy set was good to excellent\/almost perfect.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our data support the\n                      <jats:styled-content style=\"fixed-case\">PRGS<\/jats:styled-content>\n                      as a reproducible and useful tool to assess response to intraperitoneal chemotherapy in PM. Future studies should evaluate the prognostic and predictive role of the\n                      <jats:styled-content style=\"fixed-case\">PRGS<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.13829","type":"journal-article","created":{"date-parts":[[2019,1,27]],"date-time":"2019-01-27T23:39:11Z","timestamp":1548632351000},"page":"1014-1024","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Reproducibility of the peritoneal regression grading score for assessment of response to therapy in peritoneal metastasis"],"prefix":"10.1111","volume":"74","author":[{"given":"Wiebke","family":"Solass","sequence":"first","affiliation":[{"name":"Institute of Pathology and Neuropathology Eberhard\u2010Karls\u2010University Tuebingen and National Center for Pleura and Peritoneum University of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Sempoux","sequence":"additional","affiliation":[{"name":"Service of Clinical Pathology Institute of Pathology Lausanne University Hospital Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5087-6874","authenticated-orcid":false,"given":"Norman J","family":"Carr","sequence":"additional","affiliation":[{"name":"Peritoneal Malignancy Institute Basingstoke and North Hampshire Hospital Basingstoke UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Bibeau","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Caen and R\u00e9seau National des Tumeurs Rares du P\u00e9ritoine (RENAPE) Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9155-5762","authenticated-orcid":false,"given":"Daniel","family":"Neureiter","sequence":"additional","affiliation":[{"name":"Institute of Pathology Paracelsus Medical University Salzburger Landeskliniken (SALK) Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarkan","family":"J\u00e4ger","sequence":"additional","affiliation":[{"name":"Department of Surgery Paracelsus Medical University Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Di Caterino","sequence":"additional","affiliation":[{"name":"Department of Pathology Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Brunel","sequence":"additional","affiliation":[{"name":"Service of Clinical Pathology Institute of Pathology Lausanne University Hospital Lausanne 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of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9466-2333","authenticated-orcid":false,"given":"S\u00f6nke","family":"Detlefsen","sequence":"additional","affiliation":[{"name":"Department of Pathology Odense University Hospital Odense Denmark"},{"name":"Odense PIPAC Center (OPC) and Odense Pancreas Center (OPAC) Odense University Hospital Odense Denmark"},{"name":"Institute of Clinical Research University of Southern Denmark Odense 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