{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:51:36Z","timestamp":1767919896876,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T00:00:00Z","timestamp":1556150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>We applied the 2017 World Health Organization (WHO) classification criteria to categorise a series of 64 primary cutaneous large B\u2010cell lymphomas (PCLBCLs), containing a majority (\u226580%) of large cells and a proliferative rate of \u226540%, raising the problem of the differential diagnosis between PCLBCL, leg type (PCLBCL\u2010LT) and primary cutaneous follicle centre lymphoma, large cell (PCFCL\u2010LC). The aims were to determine the reproducibility and prognostic relevance of the 2017 WHO criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Morphology and phenotype identified 32 PCLBCLs\u2010LT and 25 PCFCLs\u2010LC; seven cases (11%) remained unclassified. Morphology was less reproducible than immunophenotype. Pertinent markers for the differential diagnosis were MUM1, FOXP1, CD10, and IgM. bcl\u20102 and bcl\u20106 were expressed by both PCFCLs\u2010LC and PCLBCLs\u2010LT at substantial levels. Neither Ki67 expression nor p63 expression was of diagnostic value. <jats:italic>MYD88<\/jats:italic> was found to be mutated only in PCLBCLs\u2010LT (<jats:italic>n<\/jats:italic> = 22, 69%). According to Hans\/Hans modified algorithms, 23 of 25 PCFCLs\u2010LC had germinal centre (GC) status, and the 32 PCLBCLs\u2010LT had non\u2010GC status. Overall survival was poorer for PCLBCLs\u2010LT than PCFCLs\u2010LC (<jats:italic>P<\/jats:italic> = 0.0002). Non\u2010GC cases had poorer overall survival than GC cases (<jats:italic>P<\/jats:italic> = 0.0007). In PCLBCLs\u2010LT, MYC expression was associated with cutaneous relapses (<jats:italic>P<\/jats:italic> = 0.014). When GC\/non\u2010GC status was applied to unclassified cases, only a single case remained discordant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results support the 2017 WHO classification criteria for PCLBCL diagnosis. The Hans modified algorithm using CD10 and MUM1 distinguished PCFCLs\u2010LC from PCLBCLs\u2010LT with optimal diagnostic value without requiring bcl\u20106 immunolabelling (poorly reproducible). Rare unclassified cases may constitute a provisionally heterogeneous subgroup for which GC\/non\u2010GC status (relevant for prognosis) may guide therapeutic decisions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13832","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T05:37:06Z","timestamp":1549345026000},"page":"1067-1080","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Primary cutaneous large B\u2010cell lymphomas: relevance of the 2017 World Health Organization classification: clinicopathological and molecular analyses of 64 cases"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9214-8592","authenticated-orcid":false,"given":"Sarah","family":"Menguy","sequence":"first","affiliation":[{"name":"Pathology Department University Hospital of Bordeaux H\u00f4pital Haut\u2010L\u00e9v\u00eaque Bordeaux France"},{"name":"INSERM U1053 Team 3 Oncogenesis of Cutaneous Lymphomas University of Bordeaux Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Beylot\u2010Barry","sequence":"additional","affiliation":[{"name":"INSERM U1053 Team 3 Oncogenesis of Cutaneous Lymphomas University of Bordeaux Bordeaux France"},{"name":"Dermatology Department University Hospital of Bordeaux H\u00f4pital Saint\u2010Andr\u00e9 Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Parrens","sequence":"additional","affiliation":[{"name":"Pathology Department University Hospital of Bordeaux H\u00f4pital Haut\u2010L\u00e9v\u00eaque Bordeaux France"},{"name":"INSERM U1053 Team 3 Oncogenesis of Cutaneous Lymphomas University of Bordeaux Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Pham","family":"Ledard","sequence":"additional","affiliation":[{"name":"INSERM U1053 Team 3 Oncogenesis of Cutaneous Lymphomas University of Bordeaux Bordeaux France"},{"name":"Dermatology Department University Hospital of Bordeaux H\u00f4pital Saint\u2010Andr\u00e9 Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Frison","sequence":"additional","affiliation":[{"name":"ISPED University Hospital of Bordeaux and University of Bordeaux Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Comoz","sequence":"additional","affiliation":[{"name":"Pathology Department University Hospital of Caen H\u00f4pital Cl\u00e9menceau Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxime","family":"Battistella","sequence":"additional","affiliation":[{"name":"Pathology Department University Hospital of Paris H\u00f4pital Saint\u2010Louis APHP Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Szablewski","sequence":"additional","affiliation":[{"name":"Pathology 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