{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:52:33Z","timestamp":1774878753499,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Xp11 rearrangement in renal cell carcinoma (RCC) typically involves gene fusion to the gene encoding transcription factor E3 (TFE3), a member of the microphthalmia\u2010associated transcription factor family on chromosome Xp11.2. Dual\u2010colour break\u2010apart fluorescence <jats:italic>in\u2010situ<\/jats:italic> hybridisation (FISH) is recommended to confirm histological diagnoses. Recently, RNA\u2010binding motif protein 10 (RBM10), encoded by a gene on chromosome Xp11.3, was identified as a chimeric partner of TFE3; thus, <jats:italic>RBM10<\/jats:italic>\u2013<jats:italic>TFE3<\/jats:italic> fusion results from paracentric inversion. <jats:italic>RBM10<\/jats:italic>\u2013<jats:italic>TFE3<\/jats:italic> RCC may yield a false\u2010negative result in FISH analysis of <jats:italic>TFE3<\/jats:italic> expression. The aim of the present study was to investigate the clinicopathological features of <jats:italic>RBM10<\/jats:italic>\u2013<jats:italic>TFE3<\/jats:italic> RCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Ten patients with <jats:italic>RBM10<\/jats:italic>\u2013<jats:italic>TFE3<\/jats:italic> RCC aged 31\u201371\u00a0years were investigated. Histological analysis, immunostaining, dual\u2010colour break\u2010apart FISH for <jats:italic>TFE3<\/jats:italic>, reverse transcription polymerase chain reaction and sequencing analysis were performed. No patient had a history of exposure to chemotherapy. Two of these patients died of RCC, and three were alive but developed metastases. Microscopically, the tumours were composed of a mixed architecture of tubulocystic and papillary patterns with scattered psammoma bodies. The tumours showed strong nuclear immunoreactivity for TFE3. FISH showed consistent closely spaced split signals in the RCCs of four patients, and polysomic signals with occasional closely spaced split signals in the RCCs of six patients. Of the latter six patients, five had renal failure, and four developed tumours in kidneys subjected to haemodialysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study suggests that the carcinogenesis of <jats:italic>RBM10<\/jats:italic>\u2013<jats:italic>TFE3<\/jats:italic> RCC in some, but not all, patients may be associated with chronic kidney disease. The aggressive nature of <jats:italic>RBM10<\/jats:italic>\u2013<jats:italic>TFE3<\/jats:italic> RCC should be considered, as five patients experienced metastases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13866","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T19:29:20Z","timestamp":1553542160000},"page":"254-265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["<i>RBM10<\/i>\u2013<i>TFE3<\/i> renal cell carcinoma characterised by paracentric inversion with consistent closely split signals in break\u2010apart fluorescence <i>in\u2010situ<\/i> hybridisation: study of 10 cases and a literature review"],"prefix":"10.1111","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7731-9509","authenticated-orcid":false,"given":"Ikuma","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Molecular Pathology Yokohama City University Graduate School of 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