{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:53:01Z","timestamp":1784335981975,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["S108-4148"],"award-info":[{"award-number":["S108-4148"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The aims of this study were to identify the genetic features of appendiceal epithelial neoplasms and correlate the genetic features with morphology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We analysed the genetic features of a series of 47 appendiceal epithelial neoplasms of various morphologies by using targeted next\u2010generation sequencing of 11 genes commonly mutated in gastrointestinal neoplasms. Seven of nine serrated polyps harboured <jats:italic>BRAF<\/jats:italic> mutations, which are rare in other types of appendiceal tumours. Most cases of low\u2010grade appendiceal mucinous neoplasms (LAMNs) exhibited <jats:italic>GNAS<\/jats:italic> and <jats:italic>KRAS<\/jats:italic> mutations. LAMNs with a coexisting serrated polyp were all <jats:italic>KRAS<\/jats:italic> mutated. Four LAMNs with mutations in the Wnt\/\u03b2\u2010catenin pathway, either through inactivating mutations in <jats:italic>APC<\/jats:italic> or <jats:italic>RNF43<\/jats:italic> or activating mutations in <jats:italic>CTNNB1<\/jats:italic>, had focal proliferation of mucin\u2010poor low\u2010grade tumour cells, reminiscent of colorectal adenomas. Mutations in the Wnt\/\u03b2\u2010catenin pathway were also identified in high\u2010grade appendiceal mucinous neoplasms, suggesting that Wnt\/\u03b2\u2010catenin pathway activation is the driving force for the progression of LAMN to a higher\u2010grade lesion. Adenomatous polyps of the appendix frequently had <jats:italic>APC<\/jats:italic>, <jats:italic>KRAS<\/jats:italic> and <jats:italic>TP53<\/jats:italic> mutations and were morphologically and molecularly similar to adenomatous polyps of the colorectum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate a close association between morphology and genetic events in appendiceal neoplasms and suggest a phylogenetic relationship between different entities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13924","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T04:58:26Z","timestamp":1558414706000},"page":"468-477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Correlation of molecular and morphological features of appendiceal epithelial neoplasms"],"prefix":"10.1111","volume":"75","author":[{"given":"Jia H","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Pathology National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Yao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Surgery National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray\u2010Hwang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Surgery National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9986-7194","authenticated-orcid":false,"given":"Yung\u2010Ming","family":"Jeng","sequence":"additional","affiliation":[{"name":"Department of Pathology National Taiwan University Hospital Taipei Taiwan"},{"name":"Graduate Institute of Pathology, College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,8]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"277","article-title":"Highlights from the 8th World Congress on Peritoneal Surface Malignancies","volume":"9","author":"Li Y","year":"2012","journal-title":"Cancer Biol. 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