{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T03:15:26Z","timestamp":1787368526867,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T00:00:00Z","timestamp":1566172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Appendicitis with a Crohn\u2019s\u2010like histological appearance generally raises concern for Crohn\u2019s disease, <jats:italic>Yersinia<\/jats:italic> infection, and interval appendectomy. <jats:italic>Actinomyces<\/jats:italic> infection is a recognised cause of chronic appendicitis that can histologically mimic Crohn\u2019s disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We report on 20 cases of appendicitis with Crohn\u2019s\u2010like histological features that were due to <jats:italic>Actinomyces<\/jats:italic>. Most patients presented with acute or chronic abdominal pain. Imaging studies suggested a mass in five cases. Two patients had interval appendectomy. Histological features showed Crohn\u2019s\u2010like appendicitis in 16 cases, with moderate to marked fibrosis and granulomas in seven cases. The other four cases had less consistent histological findings. None of the patients developed Crohn\u2019s disease during the follow\u2010up interval (median, 37\u00a0months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>Actinomyces<\/jats:italic> can be associated with Crohn\u2019s\u2010like appendicitis with marked fibrosis, transmural inflammation, lymphoid hyperplasia, and granulomas.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13929","type":"journal-article","created":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T02:59:32Z","timestamp":1559530772000},"page":"486-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["<i>Actinomyces<\/i> in Crohn\u2019s\u2010like appendicitis"],"prefix":"10.1111","volume":"75","author":[{"given":"Bela A","family":"Horvath","sequence":"first","affiliation":[{"name":"Eastern Connecticut Pathology Consultants Manchester CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Maryamchik","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital, Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1728-0825","authenticated-orcid":false,"given":"Gregory C","family":"Miller","sequence":"additional","affiliation":[{"name":"Envoi Specialist Pathologists Kelvin Grove Brisbane Queensland Australia"},{"name":"Faculty of Medicine University of Queensland Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian S","family":"Brown","sequence":"additional","affiliation":[{"name":"Envoi Specialist Pathologists Kelvin Grove Brisbane Queensland Australia"},{"name":"Faculty of Medicine University of Queensland Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6060-4717","authenticated-orcid":false,"given":"Namrata","family":"Setia","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony R","family":"Mattia","sequence":"additional","affiliation":[{"name":"Department of Pathology Newton\u2010Wellesley Hospital Newton MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Lamps","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y","family":"Lauwers","sequence":"additional","affiliation":[{"name":"Department of Pathology H. Lee Moffitt Cancer Center &amp; Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital, Harvard Medical School Boston MA USA"},{"name":"Department of Medicine, Infectious Diseases Unit Massachusetts General Hospital, Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8912-6889","authenticated-orcid":false,"given":"Joseph","family":"Misdraji","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital, Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2006.06.009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i3.395"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.03.057"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(93)90238-C"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v2.i12.888"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-010-2689-z"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(01)00875-4"},{"key":"e_1_2_6_9_1","first-page":"975","article-title":"Another look at chronic appendicitis resembling Crohn\u2019s disease","volume":"9","author":"Huang JC","year":"1996","journal-title":"Mod. 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