{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:08:08Z","timestamp":1790770088325,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T00:00:00Z","timestamp":1566172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["SAF2015\u201064885\u2010R"],"award-info":[{"award-number":["SAF2015\u201064885\u2010R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003741","name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003741","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Mantle cell lymphoma (MCL) is a heterogeneous disease with an aggressive behaviour in most cases, which is associated with expression of sex determining region\u2010Y\u2010box11 (SOX11). Experimental studies have shown that SOX11 expression is associated with an angiogenic switch characterised by increased expression of angiogenic\u2010related signatures and vascularisation of murine tumours. However, the relationship between angiogenesis and SOX11 expression in primary tumours is not well understood. Therefore, the aim of this study was to evaluate the development of microvascular angiogenesis in primary MCL in relation to SOX11 expression and its potential prognostic value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Fifty\u2010six patients diagnosed with MCL, 38 SOX11\u2010positive and 18 SOX11\u2010negative, were studied. The relative intratumoral microvascular area (MVA) and microvessel density (MVD) (number of intratumoral microvessels\/\u03bcm<jats:sup>2<\/jats:sup>) were measured on CD34\u2010stained slides using a computerised image analysis system. SOX11\u2010positive MCL showed a significant higher microvascular development than negative tumours (median MVA\u00a0=\u00a014.5\u00a0\u00d7\u00a010<jats:sup>\u22123<\/jats:sup> versus 5.0\u00a0\u00d7\u00a010<jats:sup>\u22123<\/jats:sup> <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001; median MVD\u00a0=\u00a018.6\/\u03bcm<jats:sup>2<\/jats:sup> versus 14.2\/\u03bcm<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.021). Analysing the MVA and MVD as continuous variables, a high MVD was associated with shorter overall survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004), and a similar tendency was observed for high MVA (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.064). The microvascular development was not related to the Ki\u201067 proliferative index or 17p\/<jats:italic>TP53<\/jats:italic>, 9p or 11q alterations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that SOX11 promotes an angiogenic phenotype in primary MCL, which may contribute to the more aggressive behaviour of these tumours.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13935","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T16:14:07Z","timestamp":1559924047000},"page":"704-714","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Increased tumour angiogenesis in SOX11\u2010positive mantle cell lymphoma"],"prefix":"10.1111","volume":"75","author":[{"given":"Georgios","family":"Petrakis","sequence":"first","affiliation":[{"name":"Pathology Department, Medical School Aristotle University of Thessaloniki Thessaloniki 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(IDIBAPS) Barcelona Spain"},{"name":"Centro de Investigacion Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC) Madrid Spain"},{"name":"Department of Hematology Hospital Clinic University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Gonzalez\u2010Farre","sequence":"additional","affiliation":[{"name":"Haematopathology Unit, Pathology Department Hospital Clinic, University of Barcelona Barcelona Spain"},{"name":"Centro de Investigacion Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Navarro","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"},{"name":"Centro de Investigacion Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC) Madrid 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