{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:47:54Z","timestamp":1792277274739,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T00:00:00Z","timestamp":1570320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Olfactory neuroblastomas (ONBs) are rare malignant tumours that arise in the nasal vault. To date, the Hyams grade remains the only widely used histological grading system. However, it is based only on morphological criteria, and has not been updated since 1988. The objective of this study was to explore the prognostic potential of the Ki67 proliferation index (PI) and tumour\u2010infiltrating lymphocytes (TILs) in ONB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      A retrospective study was conducted on a bicentric series of 45 cases. The Ki67 PI was determined by counting at least 1000 nuclei on whole slides. TILs were evaluated with CD20, CD4 and CD8 immunohistochemical markers on whole slides. In this series, Hyams grades I, II, III and IV accounted for 13.4%, 44.4%, 20% and 22.2% of all cases, respectively. The Ki67 PI ranged from 1 to 93; the Ki67 PI was significantly higher in Hyams grade III\u2013IV ONBs than in Hyams grade I\u2013II ONBs (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001). A Ki67 PI of \u226525 was associated with poorer survival (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.02). TILs were present in both stromal and intratumoral compartments, but were located predominantly in the stromal component of the tumour. The numbers of intratumoral CD8+ cells\/mm\n                      <jats:sup>2<\/jats:sup>\n                      and CD4+ cells\/mm\n                      <jats:sup>2<\/jats:sup>\n                      were greater in high\u2010grade ONBs than in low\u2010grade ONBs (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0015 and\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.043, respectively). The numbers of T cells\/mm\n                      <jats:sup>2<\/jats:sup>\n                      and B cells\/mm\n                      <jats:sup>2<\/jats:sup>\n                      were not associated with survival, but a CD4\/CD8 ratio of &gt;2 was significantly associated with shorter survival (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that the Ki67 PI and TILs could be used as prognostic markers, as a potential alternative to the Hyams grade.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.13954","type":"journal-article","created":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T13:35:04Z","timestamp":1563197704000},"page":"853-864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Evaluating the prognostic potential of the Ki67 proliferation index and tumour\u2010infiltrating lymphocytes in olfactory neuroblastoma"],"prefix":"10.1111","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0802-6585","authenticated-orcid":false,"given":"Marion","family":"Classe","sequence":"first","affiliation":[{"name":"Department of Pathology Institut Gustave Roussy Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Burgess","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery Assistance Publique\u2013Hopitaux de Paris Lariboisi\u00e8re Hospital Paris 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