{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:12:55Z","timestamp":1785683575141,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007052","name":"Memorial Sloan-Kettering Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Patients with aggressive CD8+ cutaneous T\u2010cell lymphomas (CTCLs) progress rapidly and respond poorly to therapy. Confounding treatment planning, there is clinicopathological overlap between aggressive CD8+ CTCLs and other lymphoproliferative disorders (LPDs). Hence, improved diagnostic methods and therapeutic options are needed. The aim of this study was to examine C\u2010C chemokine receptor 4 (CCR4) expression as a diagnostic and therapeutic biomarker in CD8+ CTCLs\/LPDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Forty\u2010nine cases (41 patients) with CD8+ CTCLs\/LPDs were examined, including CD8+ mycosis fungoides (MF) (<jats:italic>n<\/jats:italic>\u00a0=\u00a014), aggressive epidermotropic CD8+ cytotoxic T\u2010cell lymphoma (AETCL) (<jats:italic>n<\/jats:italic>\u00a0=\u00a08), subcutaneous panniculitis\u2010like T\u2010cell lymphoma (SPTCL) (<jats:italic>n<\/jats:italic>\u00a0=\u00a07), CD30+ LPDs (<jats:italic>n<\/jats:italic>\u00a0=\u00a06), primary cutaneous \u03b3\u03b4 T\u2010cell lymphoma (GDTCL) (<jats:italic>n<\/jats:italic>\u00a0=\u00a06), and others (<jats:italic>n<\/jats:italic>\u00a0=\u00a08). Immunohistochemical tissue staining was performed with a CCR4 monoclonal antibody on formalin\u2010fixed paraffin\u2010embedded tissue sections. CCR4 immunostaining was graded as percentage infiltrate, i.e. high (&gt;25%) and low (\u226425%), and the results were correlated with clinicopathological diagnoses. CCR4 expression was seen in 69% of the studied cases. Any CCR4 positivity was seen in all CD8+ MF cases, in 83% of CD30+ LPD cases, in 75% of AETCL cases, in 33% of GDTCL cases, and in none of the SPTCL cases. High CCR4 expression was seen in 79% of CD8+ MF cases versus 33% of CD30+ LPD cases, in 17% of GDTCL cases, and in 12.5% of AETCL cases. Patients with more advanced MF stage had higher CCR4 expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CCR4 immunohistochemistry may be an adjunct in distinguishing advanced CD8+ MF from other CD8+ CTCLs\/LPDs. Although CCR4 expression may justify therapeutic targeting of this receptor in CD8+ MF, the role of such therapies in other CD8+ CTCLs\/LPDs is not yet clear.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13960","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T15:14:21Z","timestamp":1564413261000},"page":"222-232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["C\u2010C chemokine receptor 4 expression in CD8+ cutaneous T\u2010cell lymphomas and lymphoproliferative disorders, and its implications for diagnosis and treatment"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1206-1057","authenticated-orcid":false,"given":"Shamir","family":"Geller","sequence":"first","affiliation":[{"name":"Dermatology Service Department of Medicine Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College New York NY USA"},{"name":"Department of Dermatology Tel Aviv Sourasky Medical Centre Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1599-0433","authenticated-orcid":false,"given":"Travis J","family":"Hollmann","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M","family":"Horwitz","sequence":"additional","affiliation":[{"name":"Department of Medicine Lymphoma Service Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia L","family":"Myskowski","sequence":"additional","affiliation":[{"name":"Dermatology Service Department of Medicine Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0606-9186","authenticated-orcid":false,"given":"Melissa","family":"Pulitzer","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College New York NY 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