{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T02:07:02Z","timestamp":1785377222865,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA006973"],"award-info":[{"award-number":["P30 CA006973"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Cellular schwannoma is a specific subtype of schwannoma, prone to misinterpretation as a malignant neoplasm. Involvement of the intracranial compartment by these tumours is extremely rare. We aim to characterise this clinicopathological subgroup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We identified a total of 20 cellular schwannomas with predominant intracranial involvement. The mean age of the patients at the time of surgery was 37\u00a0years (range\u00a0=\u00a016\u201381), with a slight female predominance (1.5:1 ratio). The most common sites were the eighth (<jats:italic>n<\/jats:italic>\u00a0=\u00a08) and fifth (<jats:italic>n<\/jats:italic>\u00a0=\u00a06) cranial nerves. Three tumours involved the anterior cranial fossa\/olfactory groove, and a single case involved the glossopharyngeal nerve. All tumours met established criteria for cellular schwannoma, and were composed of interlacing fascicles of spindle cells lacking Verocay bodies with minimal Antoni B pattern and variable chronic inflammation and foamy histiocytes. Rare findings included haemosiderin deposition (<jats:italic>n<\/jats:italic>\u00a0=\u00a06), necrosis (<jats:italic>n<\/jats:italic>\u00a0=\u00a04), brisk mitotic activity (&gt;10 mitoses per 10 high\u2010power fields) (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), focal epithelioid morphology (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), myxoid areas (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), neuroblastoma\u2010like pattern (<jats:italic>n<\/jats:italic>\u00a0=\u00a01) and granular cells (<jats:italic>n<\/jats:italic>\u00a0=\u00a01). Immunohistochemical stains demonstrated expression of Schwann cell markers (S100 protein, SOX10, collagen IV) and preserved H3 K27 trimethylation in all cases tested. Fourteen patients had postoperative follow\u2010up, ranging from 2\u00a0months to 21\u00a0years (mean\u00a0=\u00a066\u00a0months). In patients with follow\u2010up, local recurrence\/persistence developed in six cases; five tumours were initially incompletely resected. No metastatic disease or deaths were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intracranial cellular schwannomas share morphological and immunophenotypical features with cellular schwannomas at others sites may demonstrate locally aggressive growth but appear to lack metastatic potential.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13967","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T05:59:00Z","timestamp":1564984740000},"page":"275-282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Intracranial cellular schwannomas: a clinicopathological study of 20 cases"],"prefix":"10.1111","volume":"76","author":[{"given":"Felipe","family":"D'Almeida Costa","sequence":"first","affiliation":[{"name":"Department of Anatomic Pathology A. C. Camargo Cancer Center Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago M","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology A. C. Camargo Cancer Center Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara A","family":"Lombardo","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Raghunathan","sequence":"additional","affiliation":[{"name":"Department of Pathology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Giannini","sequence":"additional","affiliation":[{"name":"Department of Pathology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Kenyon","sequence":"additional","affiliation":[{"name":"Department of Pathology Thomas Jefferson University Hospital Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali G","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Mississippi Jackson MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Gokden","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Arkansas Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C","family":"Burger","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto J","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University Baltimore MD USA"},{"name":"The Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,13]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"WHO classification of tumours. 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