{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T15:23:14Z","timestamp":1767972194935,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Chondroblastomas (CB) are rare bone tumours that typically arise in the epiphysis\/apophysis of long bones in skeletally immature patients. We explore the clinicopathological features of CB presenting in adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>CB in patients \u226520\u00a0years of age were retrieved from our institutional archives. Thirty\u2010nine CB were identified (29 male\/10 female; aged 20\u201354\u00a0years). Twenty (51%) cases occurred in long tubular bones, 10 (26%) in small bones of the feet, five (13%) in flat bones and four (10%) in the patella. All cases showed classic cytological features of CB, and chondroid matrix was universally present. Calcification was identified in 10 cases (26%), including various combinations of serpiginous (<jats:italic>n<\/jats:italic>\u00a0=\u00a07), punctate (<jats:italic>n<\/jats:italic>\u00a0=\u00a06), classic chicken\u2010wire (<jats:italic>n<\/jats:italic>\u00a0=\u00a04) and psammomatous (<jats:italic>n<\/jats:italic>\u00a0=\u00a02) patterns. Haemosiderin (<jats:italic>n<\/jats:italic>\u00a0=\u00a019), woven bone (<jats:italic>n<\/jats:italic>\u00a0=\u00a013), secondary aneurysmal bone cyst formation (<jats:italic>n<\/jats:italic>\u00a0=\u00a08), foamy macrophages (<jats:italic>n<\/jats:italic>\u00a0=\u00a04), hyalinised vascular spaces (<jats:italic>n<\/jats:italic>\u00a0=\u00a02) and cholesterol clefts (<jats:italic>n<\/jats:italic>\u00a0=\u00a02) were noted. Follow\u2010up information (<jats:italic>n<\/jats:italic>\u00a0=\u00a032, 1\u2013452\u00a0months) revealed local recurrence in three patients, all &gt;40\u00a0years of age with flat bone origin, one of which developed pulmonary metastases 132\u00a0months after initial diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CB in patients &gt;20\u00a0years of age more frequently involves the short bones of the hands\/feet and flat bones compared to those arising in their younger counterparts. A subset may harbour extensive serpiginous or psammomatous calcification rather than the classic chicken\u2010wire pattern. Although the overall local recurrence rate in adulthood is approximately 10%, all three patients with recurrent disease had tumours involving flat bones, suggesting that tumours arising in these sites may behave more aggressively.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.13972","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T14:36:03Z","timestamp":1566311763000},"page":"308-317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Chondroblastomas presenting in adulthood: a study of 39 patients with emphasis on histological features and skeletal distribution"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4751-7678","authenticated-orcid":false,"given":"Ivy","family":"John","sequence":"first","affiliation":[{"name":"Department of Anatomic Pathology University of Pittsburgh Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrie Y","family":"Inwards","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris E","family":"Wenger","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Don D","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pittsburgh Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2336-3691","authenticated-orcid":false,"given":"Karen J","family":"Fritchie","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,26]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"969","article-title":"Benign chondroblastoma of bone: a reinterpretation of the so\u2010called calcifying or chondromatous giant cell tumor","volume":"18","author":"Jaffe HL","year":"1942","journal-title":"Am. 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