{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:29:58Z","timestamp":1792715398690,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T00:00:00Z","timestamp":1576540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Vulval squamous cell carcinoma (VSCC) can arise through two distinct pathways [human papillomavirus (HPV)\u2010associated and HPV\u2010independent], and these VSCC variants are recognised as different disease entities on the basis of different aetiologies, morphological features, molecular events during oncogenesis, precursor lesions, prognosis, and response to treatment. The precursor of HPV\u2010associated VSCC, variously referred to as high\u2010grade squamous intraepithelial lesion (HSIL) [vulvar intraepithelial neoplasia (VIN) 2\/3] or usual\u2010type VIN, is morphologically identical to the more common HSIL (cervical intraepithelial neoplasia 2\/3) of the cervix. The precursor lesions of HPV\u2010independent VSCC include differentiated VIN, differentiated exophytic vulvar intraepithelial lesion, and vulvar acanthosis with altered differentiation; these have been under\u2010recognised by pathologists in the past, leading to delays in treatment. This review will discuss the recent advances in diagnostic surgical pathology of VSCC and its precursors, and how these diagnoses can impact on patient management.<\/jats:p>","DOI":"10.1111\/his.13989","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T13:12:05Z","timestamp":1576588325000},"page":"128-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Vulval squamous cell carcinoma and its precursors"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1782-1967","authenticated-orcid":false,"given":"Naveena","family":"Singh","sequence":"first","affiliation":[{"name":"Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7889-8250","authenticated-orcid":false,"given":"C Blake","family":"Gilks","sequence":"additional","affiliation":[{"name":"Vancouver General Hospital Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,17]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"SEER cancer stat facts: Vulvar cancer"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-90-481-9485-8_17"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2012.160"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90294-Y"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199104000-00001"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199302000-00005"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1994.1039"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00351-7"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213251.82940.bf"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0209"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13205"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2001.6466"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000263"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000454"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.12.013"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2011.01.006"},{"key":"e_1_2_13_18_1","first-page":"131","article-title":"Molecular pathogenesis of cancer of the cervix and its causation by specific human papillomavirus types","volume":"186","author":"Hausen H","year":"1994","journal-title":"Curr. 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