{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T14:54:17Z","timestamp":1758812057485,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The clinical significance of common histological parameters in acute interstitial nephritis (AIN) is uncertain. We aimed to evaluate the utility of histology in predicting clinical outcomes in patients with AIN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Adult renal biopsies yielding a diagnosis of AIN between 2000 and 2015 were re\u2010examined. Patients were divided into groups based on: (i) the percentage of non\u2010fibrotic cortex containing inflammation (NFI score) (NFI\u20101\u00a0=\u00a00\u201324%; NFI\u20102\u00a0=\u00a025\u201374%; NFI\u20103\u00a0=\u00a075\u2013100%) and (ii) the percentage of cortex containing tubular atrophy (TA score) (TA1\u00a0=\u00a00\u20139%; TA2\u00a0=\u00a010\u201324%; TA3\u00a0=\u00a025\u2013100%). The primary outcome was a composite of \u226550% reduction in serum creatinine (sCr) or an estimated glomerular filtration rate (eGFR)\u00a0&gt;\u00a060\u00a0ml\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup> 1\u00a0year post\u2010biopsy. From a total of 2817 native renal biopsies, there were 120 patients with AIN and adequate data for analysis. Of these, 66 (56%) achieved the primary outcome. On univariable logistic regression, NFI\u20103 was associated with a 16 times increased likelihood of achieving the primary outcome compared to NFI\u20101 [odds ratio (OR)\u00a0=\u00a016, 95% confidence interval (CI)\u00a0=\u00a05.2\u201350)]. In contrast, TA3 was associated with a 90% reduced likelihood of achieving the primary outcome compared to TA1 (OR\u00a0=\u00a00.10, 95% CI\u00a0=\u00a00.0\u20130.3). Maximal clinical utility was achieved by combining TA and NFI into a single prognostic \u2018TANFI\u2019 score, which had an independent predictive effect on the primary outcome in a multivariable regression model consisting of age, sex, baseline sCr and identified drug cause.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with biopsy\u2010proven AIN, a lower percentage of cortical tubular atrophy and, paradoxically, a higher percentage of inflammation in non\u2010fibrosed cortex were associated with an increased likelihood of a positive clinical outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14031","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T05:10:16Z","timestamp":1573017016000},"page":"698-706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Predicting outcome in acute interstitial nephritis: a case\u2013series examining the importance of histological parameters"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9031-481X","authenticated-orcid":false,"given":"Alastair J","family":"Rankin","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences University of Glasgow Glasgow UK"},{"name":"Glasgow Renal and Transplant Unit Queen Elizabeth University Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Cannon","sequence":"additional","affiliation":[{"name":"Glasgow Renal and Transplant Unit Queen Elizabeth University Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Gillis","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences University of Glasgow Glasgow UK"},{"name":"Glasgow Renal and Transplant Unit Queen Elizabeth University Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Crosby","sequence":"additional","affiliation":[{"name":"Department of Pathology Queen Elizabeth University Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3387-2123","authenticated-orcid":false,"given":"Patrick B","family":"Mark","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin C","family":"Geddes","sequence":"additional","affiliation":[{"name":"Glasgow Renal and Transplant Unit Queen Elizabeth University Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan G","family":"Fox","sequence":"additional","affiliation":[{"name":"Glasgow Renal and Transplant Unit Queen Elizabeth University Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Mackinnon","sequence":"additional","affiliation":[{"name":"Glasgow Renal and Transplant Unit Queen Elizabeth University Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily P","family":"McQuarrie","sequence":"additional","affiliation":[{"name":"Glasgow Renal and Transplant Unit Queen Elizabeth University Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Kipgen","sequence":"additional","affiliation":[{"name":"Department of Pathology Queen Elizabeth University Hospital Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcu236"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-017-0747-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.04.027"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.89"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.5414\/CN10838"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfx247"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh485"},{"key":"e_1_2_7_9_1","first-page":"2527","article-title":"Diagnosis and management of acute interstitial nephritis","volume":"67","author":"Kodner CM","year":"2003","journal-title":"Am. 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Kidney J."},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfy093"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.6.1081"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.14031","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/his.14031","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.14031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T22:28:12Z","timestamp":1694039292000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.14031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,10]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/his.14031"],"URL":"https:\/\/doi.org\/10.1111\/his.14031","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"type":"print","value":"0309-0167"},{"type":"electronic","value":"1365-2559"}],"subject":[],"published":{"date-parts":[[2020,3,10]]},"assertion":[{"value":"2019-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}