{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:36:20Z","timestamp":1790699780161,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To clinicopathologically characterise a subset of aspergillosis cases characterised by radiologically solid lung nodules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We reviewed our archives for lung biopsies\/resections with fungal hyphae on histology. Cases classifiable as a well\u2010established form of aspergillosis were excluded. Unclassifiable cases with radiologically solid lung nodules and histological evidence of fungal hyphae consistent with <jats:italic>Aspergillus<\/jats:italic> were analysed in detail. Of 134 lung biopsies\/resections with fungal hyphae, eight presented as a solid lung nodule on imaging and could not be classified as a well\u2010recognised form of aspergillosis. All patients were non\u2010immunocompromised\/minimally immunocompromised adult smokers. Imaging showed solid, predominantly solitary, spiculated, subpleural, hypermetabolic upper lobe nodules in emphysematous lungs. Malignancy was suspected clinically in all cases. Histologically, the nodules were necrotising granulomas containing fungal hyphae consistent with <jats:italic>Aspergillus<\/jats:italic>. On follow\u2010up, none of the nodules recurred or progressed to invasive disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Aspergillosis can present as a radiologically solid, spiculated lung nodule suspicious for malignancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14037","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T19:00:08Z","timestamp":1574190008000},"page":"685-697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Expanding the spectrum of chronic necrotising (semi\u2010invasive) aspergillosis: a series of eight cases presenting as radiologically solid lung nodules mimicking malignancy"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1139-2914","authenticated-orcid":false,"given":"Josephine K","family":"Dermawan","sequence":"first","affiliation":[{"name":"Department of Pathology Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subha","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Thoracic Radiology Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Department of Thoracic Radiology Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.140.2.7255704"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198203000-00005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(97)90173-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.174.1.1740051"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2001.tb00006.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.21.4.g01jl03825"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPO8VTSK3HRNUT"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-015-0388-8"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-206291"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5858\/2008-132-606-TPOPDD"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.5858\/134.5.667","article-title":"Granulomatous lung disease: an approach to differential diagnosis","volume":"134","author":"Mukhopadhyay S","year":"2010","journal-title":"Arch. 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