{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:21:15Z","timestamp":1788391275318,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004100","name":"Labex","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004100","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Primary prostatic lymphomas (PPL) is exceedingly rare. The aim of this study was to investigate the largest series of PPL obtained from a nationwide expert pathologist network, and thus try to understand the pathophysiology of these tumours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Up to 66\u00a0000 lymphoma cases have been collected and submitted for central expert review by the French Lymphopath network. We confirm the low frequency of PPL (<jats:italic>n<\/jats:italic>\u00a0=\u00a077; 0.12%), all cases being of B\u2010cell origin. Diffuse large B\u2010cell lymphoma and small lymphocytic lymphoma were the most frequent subtypes, comprising 31% and 26% of cases respectively, followed by mucosa\u2010associated lymphoid tissue (MALT)\/lymphoplasmacytic lymphoma (19%), follicular lymphoma (12%), mantle cell lymphoma (6%), Burkitt lymphoma (4%), and unclassified lymphoma (1%). Clinical data obtained in 25 cases suggests that PPLs are rather indolent tumours. Our hypothesis for B\u2010cell recruitment in the prostatic tissue was derived from the observation in chronic inflammation (prostatitis) of frequent heterotopic proliferation of high endothelial venules (HEVs). The latter are dedicated to lymphocyte entry into secondary lymphoid organs, here putatively driving circulating clonal B\u2010lymphocytes from the blood into the inflamed prostate. This may account for the relatively high incidence of small lymphocytic lymphoma consistently reported in series of primary or secondary prostatic lymphoma. As in other organs or glands, chronic inflammation may promote antigen\u2010dependent intraprostatic MALT lymphoma and diffuse large B\u2010cell lymphoma development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PPLs are exclusively of B\u2010cell origin, and chronic inflammation resulting from the proliferation of high endothelial venules could play some role in their development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14045","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T10:10:54Z","timestamp":1576059054000},"page":"767-773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Exclusive B\u2010cell phenotype of primary prostatic lymphomas: a potential role of chronic prostatitis"],"prefix":"10.1111","volume":"76","author":[{"given":"Sarah","family":"P\u00e9ricart","sequence":"first","affiliation":[{"name":"Department of Pathology Institut Universitaire du Cancer de Toulouse Toulouse France"},{"name":"Cancer Research Centre of Toulouse INSERM UMR1037 Toulouse France"},{"name":"Labex TOUCAN Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Syrykh","sequence":"additional","affiliation":[{"name":"Department of Pathology Institut Universitaire du Cancer de Toulouse Toulouse France"},{"name":"Cancer Research Centre of Toulouse INSERM UMR1037 Toulouse France"},{"name":"Labex TOUCAN Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Amara","sequence":"additional","affiliation":[{"name":"Department of Pathology Institut Universitaire du Cancer de Toulouse Toulouse France"},{"name":"Cancer Research Centre of Toulouse INSERM UMR1037 Toulouse France"},{"name":"Labex TOUCAN Toulouse 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France"},{"name":"Institut de Pharmacologie et de biologie Structurale (IPBS) Universit\u00e9 de Toulouse CNRS UPS Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loic","family":"Ysebaert","sequence":"additional","affiliation":[{"name":"Cancer Research Centre of Toulouse INSERM UMR1037 Toulouse France"},{"name":"Department of Haematology Institut Universitaire du Cancer de Toulouse\u2010Oncopole Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5375-7512","authenticated-orcid":false,"given":"Camille","family":"Laurent","sequence":"additional","affiliation":[{"name":"Department of Pathology Institut Universitaire du Cancer de Toulouse Toulouse France"},{"name":"Cancer Research Centre of Toulouse INSERM UMR1037 Toulouse France"},{"name":"Labex TOUCAN Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8629-3291","authenticated-orcid":false,"given":"Pierre","family":"Brousset","sequence":"additional","affiliation":[{"name":"Department of Pathology Institut Universitaire du Cancer de Toulouse Toulouse France"},{"name":"Cancer Research Centre of Toulouse INSERM UMR1037 Toulouse France"},{"name":"Labex TOUCAN Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655998750015665"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0936-6555(05)80020-2"},{"key":"e_1_2_9_4_1","first-page":"225","volume-title":"Biopsy pathology of the prostate","author":"Bostwick 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