{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:49:11Z","timestamp":1790624951167,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Renal cell carcinomas are relatively rare in children and young adults. While well characterised in adults, the morphological and molecular characterisation of these tumours in young patients is relatively lacking. The objective of this study was to explore the spectrum of renal cell carcinoma (RCC) subtypes in children and young adults and to determine their clinico\u2013pathological, immunohistochemical and molecular characteristics by evaluating a large retrospective cohort of renal cell carcinoma patients age 30\u00a0years or younger.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Sixty\u2010eight cases with confirmed diagnosis of renal cell carcinoma at age 30\u00a0years or younger were identified at our institution. Clear cell carcinoma accounted for the most common subtype seen in this age group. Translocation renal cell carcinoma and rare familial syndrome subtypes such as succinate dehydrogenase deficient renal cell carcinoma and tuberous sclerosis complex\u2010associated renal cell carcinoma were found relatively more frequently in this cohort. Despite applying the 2016 WHO classification criteria, a high proportion of the tumours in our series remained unclassified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results suggest that renal cell carcinoma in children and young adults is a relatively rare disease that shares many histological similarities to renal cell carcinoma occurring in adults and yet demonstrate some unique clinical\u2013pathological differences. Microphthalmia\u2010associated transcription (MiT) family translocation RCC and rare familial syndrome subtypes are relatively more frequent in the paediatric and adolescent age groups than in adults. Clear cell RCC still accounted for the most common subtype seen in this age group. MiT family translocation RCC patients presented with advanced stage disease and had poor clinical outcomes. The large and heterogeneous subgroup of unclassified renal cell carcinoma contains phenotypically distinct tumours with further potential for future subcategories in the renal cell carcinoma classification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.14051","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T02:01:47Z","timestamp":1577152907000},"page":"875-887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinicopathological characterisation of renal cell carcinoma in young adults: a contemporary update and review of literature"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7865-9284","authenticated-orcid":false,"given":"Eman","family":"Abdulfatah","sequence":"first","affiliation":[{"name":"Department of Pathology University of Michigan Medical School Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Medical School Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Hafez","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan Medical School Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S","family":"Davenport","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan Medical School Ann Arbor MI USA"},{"name":"Department of Radiology University of Michigan Medical School Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Medical School Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon Z","family":"Weizer","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan Medical School Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh S","family":"Palapattu","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan Medical School Ann Arbor MI USA"},{"name":"Department of Urology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd M","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan Medical School Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Mannan","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Medical School Ann Arbor MI USA"},{"name":"Michigan Center for Translational Pathology Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010ming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Medical School Ann Arbor MI USA"},{"name":"Michigan Center for Translational Pathology Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saravana M","family":"Dhanasekaran","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Medical School Ann Arbor MI USA"},{"name":"Michigan Center for Translational Pathology Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel D","family":"Kaffenberger","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan Medical School Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel E","family":"Spratt","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Michigan Medical School Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Kunju","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Medical School Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Medical School Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madelyn","family":"Lew","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Medical School Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M","family":"Udager","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Medical School Ann Arbor MI USA"},{"name":"Michigan Center for Translational Pathology Ann Arbor MI USA"},{"name":"Rogel Cancer Center Michigan Medicine Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arul M","family":"Chinnaiyan","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Medical School Ann Arbor MI USA"},{"name":"Department of Urology University of Michigan Medical School Ann Arbor MI USA"},{"name":"Michigan Center for Translational Pathology Ann Arbor MI USA"},{"name":"Rogel Cancer Center Michigan Medicine Ann Arbor MI USA"},{"name":"Howard Hughes Medical Institute Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6955-8884","authenticated-orcid":false,"given":"Rohit","family":"Mehra","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Medical School Ann Arbor MI USA"},{"name":"Michigan Center for Translational Pathology Ann Arbor MI USA"},{"name":"Rogel Cancer Center Michigan Medicine Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.07.130"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21779"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199809)31:3<153::AID-MPO5>3.0.CO;2-A"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2005.06.104"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)49242-1"},{"key":"e_1_2_8_7_1","first-page":"489","article-title":"Clinicopathologic features of renal cell carcinoma in young adults: a comparison study with renal cell carcinoma in older patients","volume":"2","author":"Suh JH","year":"2009","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.11.035"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.02.029"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)54948-4"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(91)80002-O"},{"key":"e_1_2_8_12_1","first-page":"575","article-title":"Renal cell carcinoma before the age of 40: prognostic factors","volume":"12","author":"Moudouni S","year":"2002","journal-title":"Prog. Urol."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.99"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-019-1297-6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2015.02.003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000248"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13735"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000720"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000508"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.10.025"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2008.03.030"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)01884-8"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000158157.57981.80"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000288231"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318031ffff"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1309\/LR5G1VMXPY3G0CUK"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1309\/98YE9E442AR7LX2X"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-004-9106-3"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(96)90344-9"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-015-0055-0"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20548"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.02.072"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000131558.32412.40"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22346"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896909333510"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1309\/EAEJTJGD5J4J3B4F"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200112000-00011"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.4693"},{"issue":"178","key":"e_1_2_8_39_1","first-page":"e3","article-title":"Xp11 translocation renal cell carcinoma: delayed but massive and lethal metastases of a chemotherapy\u2010associated secondary malignancy","volume":"70","author":"Rais\u2010Bahrami S","year":"2007","journal-title":"Urology"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000632"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13395"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2018-0216-RA"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers9090111"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.14051","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.14051","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/his.14051","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.14051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T09:57:53Z","timestamp":1693994273000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.14051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,27]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1111\/his.14051"],"URL":"https:\/\/doi.org\/10.1111\/his.14051","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,27]]},"assertion":[{"value":"2019-10-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}