{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T22:54:08Z","timestamp":1773096848760,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To describe additional cases of nodular and polypoid sclerosing lesions of the gastrointestinal tract (GIT) that are associated with numerous IgG4\u2010positive plasma cells, review the pertinent literature to ascertain the relationship with systemic IgG4\u2010related disease, and provide a reporting framework for such lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Five new cases of sclerosing polyps or nodules were collected over a 10\u2010year period, occurring in four females and one male ranging in age from 32\u00a0years to 56\u00a0years (mean, 41.6\u00a0years). Patients were asymptomatic or had epigastric pain, and one had rectal bleeding. None had autoimmune or other obvious IgG4\u2010related disease, and serum IgG4 levels were normal. All were solitary nodules in the stomach (two cases), ileum, caecum, and rectum. Four lesions were submucosal and one was subserosal; all were well circumscribed, composed of hyalinised, keloidal fibrous tissue with lymphoplasmacytic inflammation. Obliterative phlebitis was not seen. Lineage\u2010specific immunomarkers were negative. In excess of 10 IgG4\u2010positive plasma cells per high\u2010power field were seen, and the IgG4\/IgG ratios were &gt;0.4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Very few IgG4\u2010related lesions in the tubular GIT are associated with disease at other sites and\/or elevated serum IgG4 levels. The majority may represent a lesion in the spectrum of IgG4\u2010related disease. The use of the term \u2018IgG4\u2010positive nodule or polyp with probable histological features of IgG4\u2010related disease\u2019 is advocated for nodular and\/or polypoid lesions in the GIT with \u226510 IgG4\u2010positive plasma cells in a high\u2010power field and an IgG\/IgG4 ratio of &gt;0.4.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14061","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T10:02:42Z","timestamp":1578650562000},"page":"832-837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A reappraisal of sclerosing nodular and\/or polypoid lesions of the gastrointestinal tract rich in IgG4\u2010positive plasma cells"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2124-515X","authenticated-orcid":false,"given":"Runjan","family":"Chetty","sequence":"first","affiliation":[{"name":"Division of Anatomical Pathology Laboratory Medicine Program University Health Network and University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200304000-00015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200402000-00022"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200403000-00019"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/106689690401200409"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gcb.2009.04.012"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1175-y"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-4-23"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1104650"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.5858\/2005-129-1148-APMTJA","article-title":"Autoimmune pancreatitis: more than just a pancreatic disease? 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