{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:04:38Z","timestamp":1775088278070,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2018\u2010800"],"award-info":[{"award-number":["2018\u2010800"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1C1B6007360"],"award-info":[{"award-number":["2018R1C1B6007360"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to investigate the clinicopathological significance of FGFR1 and c\u2010MYC expression, particularly in relation to angiogenesis in clear cell renal cell carcinoma (CCRCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Immunohistochemistry and fluorescence <jats:italic>in\u2010situ<\/jats:italic> hybridisation were conducted with tissue microarrays from 91 metastatic CCRCC patients who received VEGF receptor tyrosine kinase inhibitors (VEGFR\u2010TKIs). The expression of angiogenic molecules, FGFR1 and c\u2010MYC, and tumoral vascular density (TVD) and mRNA expression and TVD of 533 CCRCCs in The Cancer Genome Atlas (TCGA) were analysed. FGFR1, pFGFR1 and c\u2010MYC expression was observed in 29.1, 74.4 and 30.8% of tumours, respectively. FGFR1<jats:sup>high<\/jats:sup> was an independent worse prognostic factor for overall (HR\u00a0=\u00a01.871, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.032) and progression\u2010free (HR\u00a0=\u00a01.976, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.016) survival. FGFR1<jats:sup>high<\/jats:sup> was significantly related to VEGFR\u2010TKI responsiveness (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.011). The presence of FGFR1<jats:sup>high<\/jats:sup>\/c\u2010MYC<jats:sup>high<\/jats:sup> showed a positive correlation with proangiogenic markers, including VEGF (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.018) and HIF\u20101\u03b1 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). FGFR1<jats:sup>high<\/jats:sup>\/c\u2010MYC<jats:sup>high<\/jats:sup> tumours showed higher TVDs together with higher VEGFR2 and PDGFR\u2010\u03b2 expression (both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). FGFR1 and c\u2010MYC expression was also positively correlated with the expression of hypoxia\u2010related and proangiogenic\u2010related genes in the TCGA data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FGFR1 and c\u2010MYC may be involved in tumour angiogenesis and FGFR1 may represent a promising therapeutic target in metastatic CCRCC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14076","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T12:37:48Z","timestamp":1580215068000},"page":"838-851","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["FGFR1 is associated with c\u2010MYC and proangiogenic molecules in metastatic renal cell carcinoma under anti\u2010angiogenic therapy"],"prefix":"10.1111","volume":"76","author":[{"given":"Jee Young","family":"Park","sequence":"first","affiliation":[{"name":"Department of Pathology Kyungpook National University 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