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In case 1, the initial biopsy of nodal MZL showed scattered EBV\u2010positive cells, which might constitute an indication of EBV\u2010induced progression. Case 2 showed heterogeneous EBV expression, a phenomenon attributable to loss of the EBV episomes during cell division, or to a secondary superinfection or reactivation of the virus. In case 3, p53 overexpression related to gene mutation and EBV\u2010encoded small RNAs were identified in the same neoplastic component. In case 4, the mucosa\u2010associated lymphoid tissue\u2010type MZL and the high\u2010grade component were identified concurrently in a patient previously treated with methotrexate for an autoimmune disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data suggest that the presence of EBV should be added to the list of potential markers to be analysed for MZL prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14101","type":"journal-article","created":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T20:49:06Z","timestamp":1583614146000},"page":"112-122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Epstein\u2013Barr virus\u2010associated large B\u2010cell lymphoma transformation in marginal zone B\u2010cell lymphoma: a series of four cases"],"prefix":"10.1111","volume":"77","author":[{"given":"Francisca Inmaculada","family":"Camacho Casta\u00f1eda","sequence":"first","affiliation":[{"name":"Pathology Department Hospital Universitario de Getafe Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Dotor","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital Universitario Puerta de Hierro Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebeca","family":"Manso","sequence":"additional","affiliation":[{"name":"Pathology Department Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paloma","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital Universitario Puerta de Hierro Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Prieto Pareja","sequence":"additional","affiliation":[{"name":"Haematology Department Fundaci\u00f3n Jim\u00e9nez D\u00edaz Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Palomo Esteban","sequence":"additional","affiliation":[{"name":"Haematology Department Fundaci\u00f3n Jim\u00e9nez D\u00edaz Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Antonio","family":"Garc\u00eda Vela","sequence":"additional","affiliation":[{"name":"Haematology Department Hospital Universitario de Getafe Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Santonja","sequence":"additional","affiliation":[{"name":"Pathology Department Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A","family":"Piris","sequence":"additional","affiliation":[{"name":"Pathology Department Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Socorro Mar\u00eda","family":"Rodr\u00edguez Pinilla","sequence":"additional","affiliation":[{"name":"Pathology Department Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,12]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"World Health Organizatoon classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow SH","year":"2017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2013.11.005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2016.08.029"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-339556"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2759"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200110000-00007"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/105.5.560"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.46.8439"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.5858\/2000-124-1520-EBVAHG","article-title":"Epstein\u2010Barr virus\u2010associated high\u2010grade B\u2010cell lymphoma of mucosal\u2010associated lymphoid tissue in a 9\u2010year\u2010old Boy","volume":"124","author":"Tao J","year":"2000","journal-title":"Arch. 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