{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:12:22Z","timestamp":1747185142447,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T00:00:00Z","timestamp":1592438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005865","name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008673","name":"Yasuda Memorial Medical Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008673","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003837","name":"Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Dermatopathic reaction is a histopathological finding of lymph nodes that usually occurs in patients with inflammatory pruritic cutaneous lesions. However, it is sometimes seen in patients with cutaneous T cell lymphoma. Adult T cell leukaemia\/lymphoma (ATLL) is a T cell malignancy caused by infection with human T cell leukaemia virus type I (HTLV\u20101), which is frequently accompanied by cutaneous lesions. However, the detailed clinicopathological characteristics of the dermatopathic reaction of lymph nodes in ATLL patients and HTLV\u20101 carriers, addressed in this study, remains to be clarified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We retrospectively analysed 18 nodal lesions with dermatopathic reaction in HTLV\u20101 carriers. Axillary and inguinal lymph nodes were the primary affected tissues. Three cases with atypical lymphoid cell infiltration were defined as ATLL with dermatopathic reaction (ATLL\u2010D), showing an abnormal T cell immunophenotype and T cell monoclonality. Two of the three ATLL\u2010D patients died 14 and 7\u00a0months after diagnosis (the third case had a very short follow\u2010up). The other 15\u00a0patients were indistinguishable from reactive lesions and were defined as HTLV\u20101\u2010associated lymphadenitis with dermatopathic reaction (HAL\u2010D). They showed an indolent clinical course, with only one case eventually transforming to aggressive disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lymph node lesions accompanied by dermatopathic reaction in HTLV1 carriers represent a spectrum that includes reactive and neoplastic conditions. HAL\u2010D should be distinguished from ATLL\u2010D, especially to avoid overtreatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14102","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T07:22:27Z","timestamp":1583997747000},"page":"133-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dermatopathic reaction of lymph nodes in HTLV\u20101 carriers: a spectrum of reactive and neoplastic lesions"],"prefix":"10.1111","volume":"77","author":[{"given":"Shigeki","family":"Chinen","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of the Ryukyus Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Miyagi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medicine University of the Ryukyus Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiya","family":"Murakami","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of the Ryukyus Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuyoshi","family":"Takatori","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Graduate School of Medicine University of the Ryukyus Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shugo","family":"Sakihama","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Graduate School of Medicine University of the Ryukyus Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwao","family":"Nakazato","sequence":"additional","affiliation":[{"name":"Department of Pathology Okinawa Prefectural Nanbu Medical Center and Children\u2019s Medical Center Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Kariya","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medicine University of the Ryukyus Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayaka","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medicine University of the Ryukyus Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenzo","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medicine University of the Ryukyus Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1205-858X","authenticated-orcid":false,"given":"Kennosuke","family":"Karube","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Graduate School of Medicine University of the Ryukyus Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198106000-00004"},{"key":"e_1_2_8_3_1","first-page":"256","article-title":"Dermatopathic lymphadenopathy. 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