{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T22:21:04Z","timestamp":1783808464947,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T00:00:00Z","timestamp":1595721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Congenital haemangiomas (CHs) can be subdivided into different subtypes [rapidly involuting CHs (RICHs), non\u2010involuting CHs (NICHs), and partially involuting CHs (PICHs)]. During the first few days of life, RICHs may be associated with transient but sometimes marked thrombocytopenia. We sought to assess the histological aspects and clinicopathological correlations of the three subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We assessed the histopathological features of 10 RICHs, 25 NICHs, and 20 PICHs, described the patients\u2019 long\u2010term clinical outcomes, and assessed clinicopathological correlations. All CHs were located in the dermis and hypodermis, and comprised both capillary lobules (with three distinct histopathological patterns) and extralobular large vessels. Most of the extralobular vessels were abnormal veins and abnormal lymphatic vessels. We did not observe significant correlations between the CH subtype, the histopathological pattern, and the time of the histopathological assessment. Interestingly, unexpected intralobular expression of podoplanin was found in neonatal biopsies of five RICHs and PICHs. Four of these five patients had concomitant thrombocytopenia. The podoplanin staining intensity decreased over time as the thrombocytopenia resolved and the tumour shrank.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The histopathological features were similar in all three subtypes of CH, and were related to the time since disease onset; we consider that RICH, PICH and NICH form a single entity and differ only in their involuting potential. Along with the transient expression of intralobular podoplanin observed in some specimens from the newborn, the lobular architecture might lead to misdiagnosis of tufted haemangioma or kaposiform haemangioendothelioma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14114","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T06:29:44Z","timestamp":1586759384000},"page":"275-283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["The histopathology of congenital haemangioma and its clinical correlations: a long\u2010term follow\u2010up study of 55 cases"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6630-0020","authenticated-orcid":false,"given":"Sophie","family":"El Zein","sequence":"first","affiliation":[{"name":"Department of Biopathology Institut Curie Paris Sciences et Lettres Research University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3508-2539","authenticated-orcid":false,"given":"Olivia","family":"Boccara","sequence":"additional","affiliation":[{"name":"Paediatric Dermatology Department Necker\u2010Enfants Malades Hospital Assistance Publique\u2010H\u00f4pitaux de Paris Paris France"},{"name":"Paris Descartes University Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Soupre","sequence":"additional","affiliation":[{"name":"Paris Descartes University Sorbonne Paris Cit\u00e9 Paris France"},{"name":"Plastic and Maxillofacial Surgery Department Necker\u2010Enfants Malades Hospital Assistance Publique\u2010H\u00f4pitaux de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre F.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Biopathology Institut Curie Paris Sciences et Lettres Research University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Bodemer","sequence":"additional","affiliation":[{"name":"Paediatric Dermatology Department Necker\u2010Enfants Malades Hospital Assistance Publique\u2010H\u00f4pitaux de Paris Paris France"},{"name":"Paris Descartes University Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore","family":"Coulomb","sequence":"additional","affiliation":[{"name":"Department of Pathology Armand Trousseau Hospital AP\u2010HP Paris France"},{"name":"Pierre et Marie Curie University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Wassef","sequence":"additional","affiliation":[{"name":"Department of Pathology Lariboisi\u00e8re Hospital Paris Diderot University Universit\u00e9 de Paris Paris 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