{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:54:28Z","timestamp":1791618868143,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG 2018 21835"],"award-info":[{"award-number":["IG 2018 21835"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>\n                    Aggressive B\u2010cell lymphomas present as a heterogeneous spectrum of disease. A primary diagnosis in the bone marrow (BM) may be challenging in terms of diagnostic classification and clinical handling, owing to limited architectural information. Aggressive B\u2010cell lymphomas can be subdivided into entities that typically present primarily in the BM, and cases with BM involvement in which the bulk of disease is present in other organs. One main topic at the 2018 BM workshop of the European Association of Haematopathology\/Society of Hematopathology was therefore aggressive B\u2010cell lymphomas with a primary BM presentation. The spectrum of cases submitted to this topic gave a good overview of commonly encountered problems, as well as unusual manifestations, and highlighted areas of imprecise disease definitions and diagnostic grey zones. The categories submitted to the workshop included cases of Burkitt lymphoma (BL) with unusual features, high\u2010grade B\u2010cell lymphomas (HG\u2010BCLs) with and without so\u2010called double\/triple\u2010hit, and diffuse large B\u2010cell lymphomas (DLBCLs) with a primary BM presentation. Areas of difficulties included the morphological boundaries of HG\u2010BCL not otherwise specified, cases with\n                    <jats:italic>MYC<\/jats:italic>\n                    and\n                    <jats:italic>bcl\u20102<\/jats:italic>\n                    or\n                    <jats:italic>bcl\u20106<\/jats:italic>\n                    translocations and terminal deoxynucleotidyl transferase (TdT) expression, which were categorised as B\u2010cell lymphoblastic leukaemia\/lymphoma if most cells showed TdT positivity, and the clinicopathological overlap between intravascular large B\u2010cell lymphoma, CD5\u2010positive DLBCL, and DLBCL with primary presentations in the BM, spleen, and liver. This review summarises our understanding of the main aggressive B\u2010cell lymphoma categories with a common primary BM presentation and potential problem areas, and makes suggestions for the immunophenotypic and genetic work\u2010up, illustrated by the interesting and challenging cases submitted to the workshop.\n                  <\/jats:p>","DOI":"10.1111\/his.14124","type":"journal-article","created":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T09:35:45Z","timestamp":1587634545000},"page":"369-379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Aggressive B\u2010cell lymphomas with a primary bone marrow presentation"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6203-7966","authenticated-orcid":false,"given":"Alberto","family":"Zam\u00f2","sequence":"first","affiliation":[{"name":"Department of Oncology University of Turin Turin Italy"},{"name":"Institute of Pathology University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Pathology NHS Grampian University of Aberdeen NHS Education for Scotland Aberdeen Scotland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5034-8150","authenticated-orcid":false,"given":"Ayoma D","family":"Attygalle","sequence":"additional","affiliation":[{"name":"Department of Histopathology Royal Marsden Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5375-7512","authenticated-orcid":false,"given":"Camille","family":"Laurent","sequence":"additional","affiliation":[{"name":"Pathology and Cytology Department Centre Hospitalo\u2010Universitaire de Toulouse Institut Universitaire du Cancer de Toulouse\u2010Oncopole Centre de Recherche en Cancerologie de Toulouse Inserm UMR1037 laboratoire d\u2019excellence TOUCAN Paul Sabatier University Toulouse III Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A","family":"Arber","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falko","family":"Fend","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Comprehensive Cancer Centre T\u00fcbingen University Hospital T\u00fcbingen 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