{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:40:54Z","timestamp":1790800854921,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602535"],"award-info":[{"award-number":["81602535"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>An ongoing outbreak of 2019 novel coronavirus (CoV) disease (COVID\u201019), caused by severe acute respiratory syndrome (SARS) CoV\u20102, has been spreading in multiple countries. One of the reasons for the rapid spread is that the virus can be transmitted from infected individuals without symptoms. Revealing the pathological features of early\u2010phase COVID\u201019 pneumonia is important for understanding of its pathogenesis. The aim of this study was to explore the pulmonary pathology of early\u2010phase COVID\u201019 pneumonia in a patient with a benign lung lesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We analysed the pathological changes in lung tissue from a 55\u2010year\u2010old female patient with early\u2010phase SARS\u2010CoV\u20102 infection. In this case, right lower lobectomy was performed for a benign pulmonary nodule. Detailed clinical, laboratory and radiological data were also examined. This patient was confirmed to have preoperative SARS\u2010CoV\u20102 infection by the use of real\u2010time reverse transcription polymerase chain reaction and RNA <jats:italic>in\u2010situ<\/jats:italic> hybridisation on surgically removed lung tissues. Histologically, COVID\u201019 pneumonia was characterised by exudative inflammation. The closer to the visceral pleura, the more severe the exudation of monocytes and lymphocytes. Perivascular inflammatory infiltration, intra\u2010alveolar multinucleated giant cells, pneumocyte hyperplasia and intracytoplasmic viral\u2010like inclusion bodies were seen. However, fibrinous exudate and hyaline membrane formation, which were typical pulmonary features of SARS pneumonia, were not evident in this case. Immunohistochemical staining results showed an abnormal accumulation of CD4+ helper T lymphocytes and CD163+ M2 macrophages in the lung tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results highlighted the pulmonary pathological changes of early\u2010phase SARS\u2010CoV\u20102 infection, and suggested a role of immune dysfunction in the pathogenesis of COVID\u201019 pneumonia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14138","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T15:03:45Z","timestamp":1588777425000},"page":"823-831","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["Pulmonary pathology of early\u2010phase COVID\u201019 pneumonia in a patient with a benign lung lesion"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4131-050X","authenticated-orcid":false,"given":"Zhi","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Pathology Renmin Hospital of Wuhan University  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology Renmin Hospital of Wuhan University  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Yu","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Colorectal and Anal Surgery Zhongnan Hospital of Wuhan University  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7645-9692","authenticated-orcid":false,"given":"Hong\u2010Lin","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Pathology Renmin Hospital of 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