{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T12:50:52Z","timestamp":1779281452051,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005595","name":"University of California","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>An indolent T\u2010lymphoblastic proliferation (iT\u2010LBP) is a benign, reactive expansion of immature terminal deoxynucleotidyl transferase (TdT)\u2010positive T cells found in extrathymic tissues. iT\u2010LBP can be challenging to distinguish from malignant processes, specifically T\u2010lymphoblastic lymphoma (T\u2010LBL), given the overlapping clinical and histological features. Recently, it has been shown that LIM domain only 2 (LMO2) is overexpressed in T\u2010LBL but not in reactive immature TdT+ T cells in the thymus. On the basis of these findings, the aim of this study was to investigate the expression of LMO2 by using immunohistochemistry and its role in differentiating iT\u2010LBPs from T\u2010LBLs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We retrospectively identified cases of iT\u2010LBP and T\u2010LBL from the pathology archives of four institutions. Seven iT\u2010LBP cases (including five new cases that have not been reported in the literature) and 13\u00a0T\u2010LBL cases were analysed. Clinical, morphological, immunophenotypic and molecular data were analysed. Immunohistochemical staining with LMO2 was performed on all iT\u2010LBP and T\u2010LBL cases. A review of five new iT\u2010LBP cases showed similar morphological, immunophenotypic and molecular features to those of previously reported cases. All iT\u2010LBP cases were negative for LMO2 (0\/7), whereas 92% of T\u2010LBL cases (12\/13) expressed LMO2; the sensitivity was 92% (confidence interval 64\u2013100%) and the specificity was 100% (confidence interval 59\u2013100%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We confirm previously published findings that iT\u2010LBP cases show highly overlapping morphological and immunophenotypic features with T\u2010LBL. Importantly, LMO2 expression is a sensitive and specific marker with which to rule out iT\u2010LBP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14176","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T20:33:41Z","timestamp":1591907621000},"page":"984-988","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["LIM domain only 2 (LMO2) expression distinguishes T\u2010lymphoblastic leukemia\/lymphoma from indolent T\u2010lymphoblastic proliferations"],"prefix":"10.1111","volume":"77","author":[{"given":"Nivaz","family":"Brar","sequence":"first","affiliation":[{"name":"California Northstate University Elk Grove CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Butzmann","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Francisco San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyoti","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raheem","family":"Peerani","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5880-9337","authenticated-orcid":false,"given":"Elizabeth A","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women\u2019s Hospital Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Grigoriadis","sequence":"additional","affiliation":[{"name":"Department of Pathology Monash Health Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beena","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pathology Monash Health Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R Maciej","family":"Tatarczuch","sequence":"additional","affiliation":[{"name":"Department of Pathology Monash Health Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger A","family":"Warnke","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1881-3440","authenticated-orcid":false,"given":"Robert S","family":"Ohgami","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Francisco San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e31828d17ec"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13434"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqv024"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1182\/blood-2006-08-039024","article-title":"The oncoprotein LMO2 is expressed in normal germinal\u2010center B cells and in human B\u2010cell lymphomas","volume":"109","author":"Natkunam Y","year":"2006","journal-title":"Blood"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPZ3J4GEEYIRRA"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318264e223"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085883"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-742148"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.09.010"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-019927"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000107"},{"key":"e_1_2_8_13_1","first-page":"6350","article-title":"Indolent T\u2010lymphblastic proliferation: report of a case involving the upper aerodigestive tract","volume":"7","author":"Yang F","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200103000-00018"},{"key":"e_1_2_8_15_1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/cyto.b.21845","article-title":"Flow cytometric features of incidental indolent T lymphoblastic proliferations","volume":"98","author":"Fromm JR","year":"2019","journal-title":"Cytom. Part B Clin. Cytom."}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.14176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.14176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/his.14176","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.14176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T21:22:28Z","timestamp":1693862548000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.14176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,24]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/his.14176"],"URL":"https:\/\/doi.org\/10.1111\/his.14176","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,24]]},"assertion":[{"value":"2020-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}