{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:39:49Z","timestamp":1776922789358,"version":"3.51.2"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Verruciform xanthoma (VX) is an uncommon lesion, seen in the oral mucosa and rarely occurring at cutaneous genital sites. Reports of exceptional VX presentations dominate the literature; herein, we assess the clinical and histological features of a cohort of routine, consecutive cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Clinicopathological features of genital VXs from four academic centres were reviewed. A cohort of 25 lesions from 24 patients (22 male, two female; median age\u00a0=\u00a062\u00a0years), occurred on the scrotum (84%), penis (8%) and perineum\/vulva (8%). VX was never suspected clinically; considerations ranged from fibroepithelial polyps to squamous cell carcinoma. Classic diagnostic criteria were present at least focally in each lesion, including verrucous architecture, prominent wedge\u2010shaped parakeratosis extending between exophytic epidermal projections and neutrophils in the stratum corneum. Xanthomatous cells were present in all cases, but scattered to rare in 24%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Consecutive genital VXs reliably exhibited classic histopathological features, although the essential finding of xanthomatous cells may be scarce. Our comparison to meta\u2010analyses of published cases found relatively fewer penile and vulvar examples. Additionally, the median age was older than in published series, which have emphasised syndromic associations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14198","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T20:16:05Z","timestamp":1593461765000},"page":"841-846","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Genital verruciform xanthoma: lessons from a contemporary multi\u2010institutional series"],"prefix":"10.1111","volume":"77","author":[{"given":"Grace","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology VCU School of Medicine Richmond VA USA"},{"name":"Department of Dermatology VCU School of Medicine Richmond VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7306-8813","authenticated-orcid":false,"given":"Mark C","family":"Mochel","sequence":"additional","affiliation":[{"name":"Department of Pathology VCU School of Medicine Richmond VA USA"},{"name":"Department of Dermatology VCU School of Medicine Richmond VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Barry","family":"Randall","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tennessee Health Sciences Center Memphis TN USA"},{"name":"Department of Pathology and Laboratory Medicine University of Tennessee Health Sciences Center Memphis TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jatin S","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Tennessee Health Sciences Center Memphis TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron M","family":"Udager","sequence":"additional","affiliation":[{"name":"Department of Pathology Michigan Medicine University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0650-1266","authenticated-orcid":false,"given":"May P","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pathology Michigan Medicine University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajiv M","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pathology Michigan Medicine University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahul B","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Tennessee Health Sciences Center Memphis TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5712-8134","authenticated-orcid":false,"given":"Adeboye O","family":"Osunkoya","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Urology Emory University School of Medicine Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0982-4607","authenticated-orcid":false,"given":"Steven C","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pathology VCU School of Medicine Richmond VA USA"},{"name":"Division of Urology Department of Surgery VCU School of Medicine Richmond VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.125205"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2018-0039-RA"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-016-0155-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-019-01123-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(02)00088-X"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1985.tb02439.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199804000-00014"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/71.2.224"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.113"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200010000-00012"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1996.tb00285.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.5858\/2005-129-e62-VXOTPN","article-title":"Verucciform xanthoma of the penis not associated with human papillomavirus infection","volume":"129","author":"Er\u015fahin C","year":"2005","journal-title":"Arch. Pathol. Lab. Med."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(74)90393-4"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(71)90134-4"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1982.01650210066022"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01470.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)80473-2"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13629"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3182957bae"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12377"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12198"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2019.02.015"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13520"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.10.1263"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhis.14198","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.14198","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/his.14198","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.14198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T02:53:31Z","timestamp":1693882411000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.14198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,15]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/his.14198"],"URL":"https:\/\/doi.org\/10.1111\/his.14198","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,15]]},"assertion":[{"value":"2020-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}