{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T15:27:30Z","timestamp":1772033250719,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Paget\u2019s disease of the perianal skin is a rare form of extramammary Paget\u2019s disease, and may be a primary intraepithelial adnexal neoplasm or secondary due to spread from an underlying colorectal lesion, nearly always colorectal adenocarcinoma. Secondary perianal Paget\u2019s disease associated with non\u2010invasive colorectal adenomas is exceedingly uncommon, with only a few reported cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Herein, we present the clinical and pathological features of the largest series of secondary perianal Paget\u2019s disease arising in association with colorectal adenomas. There was gender parity and the median age was 72\u00a0years (range\u00a0=\u00a068\u201376\u00a0years). In all cases, perianal Paget\u2019s disease was associated with colorectal adenomas, including three (75%) conventional tubular adenomas and one (25%) tubulovillous adenoma with serrated foci. All adenomas had high\u2010grade dysplasia and one had intramucosal adenocarcinoma (lamina propria invasion; Tis), but all lacked submucosal invasion. The intraepithelial Paget\u2019s cells showed a colorectal phenotype by immunohistochemistry in all cases. At follow\u2010up, two patients had no evidence of disease at 6 and 87\u00a0months, one had residual perianal Paget\u2019s disease at 8\u00a0months and one developed invasive adenocarcinoma of the perianal tissue at 36\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Similar to its mammary analogue, secondary perianal Paget\u2019s disease may arise in association with invasive and\/or <jats:italic>in\u2010situ<\/jats:italic> colorectal lesions. Although the latter is an uncommon presentation of a recognised rare disease, knowledge of this phenomenon is important to forestall overdiagnosis of invasion and potential overtreatment. The clinical course is variable, such that close follow\u2010up is required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14218","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T03:00:45Z","timestamp":1595559645000},"page":"276-280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Perianal Paget\u2019s disease as spread from non\u2010invasive colorectal adenomas"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5818-2933","authenticated-orcid":false,"given":"Danielle","family":"Hutchings","sequence":"first","affiliation":[{"name":"Department of Pathology Johns Hopkins Medical Institutions Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Windon","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins Medical Institutions Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naziheh","family":"Assarzadegan","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins Medical Institutions Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevan J","family":"Salimian","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins Medical Institutions Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2611-7576","authenticated-orcid":false,"given":"Lysandra","family":"Voltaggio","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins Medical Institutions Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins Medical Institutions Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"87","article-title":"On disease of the mammary areola preceding cancer of the mammary gland","volume":"10","author":"Paget J","year":"1874","journal-title":"St Bartholomew\u2019s Hosp. 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