{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:47:06Z","timestamp":1780386426856,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Blue naevi are uncommon dermal melanocytic neoplasms characterised by <jats:italic>GNAQ<\/jats:italic>\/<jats:italic>GNA11<\/jats:italic> mutations, which very rarely progress to melanoma. Such melanomas also often have <jats:italic>BAP1<\/jats:italic> mutations, and lack genetic events associated with conventional melanoma. Exceptionally, blue naevi arise in extracutaneous locations; one melanoma arising in this setting has been reported. We report the clinicopathological, immunohistochemical and molecular genetic features of two cases of melanoma arising in extracutaneous blue naevus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Both arose in males, aged 25 and 63\u00a0years, with no history of other melanocytic lesions, and presented as large, painful intra\u2010abdominal masses. The tumours were dark\u2010brown\/black, multilobulated, involved small intestinal mesentery and consisted of a predominantly fascicular and spindled, but occasionally nested and epithelioid, proliferation of variably pigmented, relatively monotonous cells with pale cytoplasm and ovoid nuclei with mild to moderate atypia. Mitotic activity was variable but generally low. Both cases showed areas of conventional and cellular blue naevus. Recurrent tumour in one case showed predominantly epithelioid morphology and greater cytological atypia and mitotic activity. One case expressed Melan\u2010A, SOX10 and CD117, with absent expression of S100 protein and DOG1; the other expressed Melan\u2010A, HMB45 and S100 protein. Next\u2010generation sequencing identified <jats:italic>GNAQ<\/jats:italic> and <jats:italic>BAP1<\/jats:italic> mutations in one case and <jats:italic>GNA11<\/jats:italic> mutation in the other. Both patients developed widespread metastatic disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Exceptionally rare, aggressive melanomas arising in extracutaneous blue naevi should be distinguished from metastatic melanoma, gastrointestinal stromal tumour and malignant melanotic nerve sheath tumour, especially given the significant therapeutic and prognostic differences between these different entities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14219","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T21:05:50Z","timestamp":1595451950000},"page":"281-289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Primary intra\u2010abdominal melanoma arising in association with extracutaneous blue naevus: a report of two cases"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7767-0278","authenticated-orcid":false,"given":"Kabeer","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA"},{"name":"Department of Laboratory Medicine and Pathology St Mary's Hospital Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0273-7351","authenticated-orcid":false,"given":"Andrew L","family":"Folpe","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital Boston MA USA"},{"name":"Division of Genetics and Genomics Boston Children's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Dana Farber Cancer Institute Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrajit P","family":"Raut","sequence":"additional","affiliation":[{"name":"Department of Surgery Brigham and Women's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1110-3753","authenticated-orcid":false,"given":"Leona A","family":"Doyle","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2017.05.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000001645"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.1068"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2010.01.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e318046eaf3"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5858\/2010-0022-RS.1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.3892\/ol.2013.1575","article-title":"Endometrioid adenocarcinoma concurrent with a blue nevus of the endometrium and uterine cervix: a case report","volume":"6","author":"Ishida M","year":"2013","journal-title":"Oncol. 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