{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:37:01Z","timestamp":1792654621652,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T00:00:00Z","timestamp":1600560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Proton pump inhibitors (PPIs) are among the most widely used medications in the United States. Most PPI users have persistent hypergastrinaemia during treatment. However, gastric neuroendocrine tumours diagnosed in long\u2010term PPI users are rarely reported. Their clinicopathological features and prognosis are not characterised. It remains unclear whether or not they can be classified as Type III sporadic tumours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We retrospectively characterised 66 gastric neuroendocrine tumours from patients without atrophic gastritis and gastrinoma from two tertiary care medical centres, including 38 tumours in patients who had used PPIs for at least 1\u00a0year and 28 tumours from patients without long\u2010term PPI use (control group, Type III tumours). Compared to controls, tumours from long\u2010term PPI users tended to be in the pT1\u20132 category (98% versus 79%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.09) and less often invaded the serosa (3% versus 18%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.08) or lymphovascular spaces (11% versus 32%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.06). Using Kaplan\u2013Meier analysis, long\u2010term PPI users had significantly longer overall survival than controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.035). While three control patients developed distant metastasis and seven died, long\u2010term PPI users were without distant metastasis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.06) or death (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) during follow\u2010up. However, five long\u2010term PPI users developed additional gastric neuroendocrine tumour(s), while none of the controls did (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results show that gastric neuroendocrine tumours of long\u2010term PPI users are probably less aggressive compared to Type III sporadic tumours and have an indolent disease course. Our findings support the classification of gastric neuroendocrine tumours in long\u2010term PPI users as a separate subtype.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14220","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T19:55:48Z","timestamp":1595534148000},"page":"865-876","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Gastric neuroendocrine tumours from long\u2010term proton pump inhibitor users are indolent tumours with good prognosis"],"prefix":"10.1111","volume":"77","author":[{"given":"Vincent Q\u2010H","family":"Trinh","sequence":"first","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanjuan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6117-9505","authenticated-orcid":false,"given":"Changqing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh Medical Center Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1572-0241.2003.04027.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.0589"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-014-9315-x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90266-F"},{"key":"e_1_2_6_6_1","first-page":"104","volume-title":"WHO classification of tumors digestive system tumors","author":"La Rosa S","year":"2019"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910201)67:3<663::AID-CNCR2820670323>3.0.CO;2-L"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.4.460"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1017972204219"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2279"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000167862.52309.7d"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.01.018"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000201276"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70174-5"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489902"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000163363.86099.9f"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv054"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/apm.12546"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.13766"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13324"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018881617038"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71964-4"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12012"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2013.878381"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2015.1054426"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-4014-0"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21020662"},{"issue":"1","key":"e_1_2_6_28_1","first-page":"S1","article-title":"Hyperplastic, dysplastic, and neoplastic enterochromaffin\u2010like\u2010cell proliferations of the gastric mucosa: classification and histogenesis","volume":"19","author":"Solcia E","year":"1995","journal-title":"Am. 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