{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T16:58:42Z","timestamp":1784739522045,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T00:00:00Z","timestamp":1602892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Recent advances in next\u2010generation sequencing have made it clear that clonal expansion of cells harbouring driver gene mutations occurs in physiologically normal epithelium. Molecular analysis of tubal epithelium has been almost exclusively confined to the <jats:italic>TP53<\/jats:italic> pathway, which is involved in serous carcinogenesis. Other oncogenic events have not been explored in detail. Here, we report the linear expansion of fallopian tubal epithelial cells exhibiting an altered \u03b2\u2010catenin profile (\u03b2\u2010catenin signature). Through molecular analyses, we determined the incidence and clinicopathological significance of \u03b2\u2010catenin signatures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We evaluated 64 specimens of surgically removed bilateral fallopian tubes. Thirty\u2010three \u03b2\u2010catenin signatures were identified in 13 cases (20.3%); these patients were significantly younger than those without \u03b2\u2010catenin signatures (median ages of 44 and 57\u00a0years, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0317). No correlation between \u03b2\u2010catenin signature and any clinical factor was observed. <jats:italic>CTNNB1<\/jats:italic> mutations were detected in three of eight \u03b2\u2010catenin signatures when tissues were microdissected and subjected to Sanger sequencing in two representative cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first report of the <jats:italic>CTNNB1<\/jats:italic> mutation in clusters of morphologically bland tubal epithelial cells. The results of this study indicate that \u03b2\u2010catenin signatures are common, and they may be a part of diverse molecular alterations occurring in normal tubal epithelium.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14227","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T22:07:14Z","timestamp":1596665234000},"page":"880-889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinicopathological and molecular analyses of linearly expanded epithelial cells with \u03b2\u2010catenin alterations, \u201c\u03b2\u2010catenin signature\u201d, in the normal fallopian tube"],"prefix":"10.1111","volume":"77","author":[{"given":"Kei","family":"Koyama","sequence":"first","affiliation":[{"name":"Department of Cellular and Organ Pathology Graduate School of Medicine Akita University Akita 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