{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:31:14Z","timestamp":1790753474826,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T00:00:00Z","timestamp":1609372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Since the description of <jats:italic>Helicobacter pylori<\/jats:italic> (HP) as the most common cause of gastritis and its neoplastic complications, numerous articles have been written about the epidemiology, clinical features, diagnostic methods, histopathology, pathogenesis, molecular biology and treatment of this infection. This review focuses on those aspects of the infection that challenge the universality of the medical implications through the lens of evolutionary science applied to medicine. The divergent epidemiological and clinical outcomes observed in different populations and the possible beneficial aspects of the infection are discussed. Also reviewed are Correa\u2019s seminal contributions to our understanding of gastric cancer in particular and postinflammatory tumours in general, and the renewed interest in intestinal metaplasia and its clinical implications.<\/jats:p>","DOI":"10.1111\/his.14245","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T15:49:41Z","timestamp":1609429781000},"page":"39-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<i>Helicobacter pylori<\/i>: an evolutionary perspective"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1692-9880","authenticated-orcid":false,"given":"Jose","family":"Jessurun","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine New York Presbyterian Hospital Weill Cornell Medicine New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.022"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14162"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-020-06193-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32404-7"},{"key":"e_1_2_10_6_1","volume-title":"Helicobacter pylori eradication as a strategy for preventing gastric cancer","author":"International Agency for Research on Cancer","year":"2014"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405053301803"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i45.6571"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3068"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2015.00578","article-title":"Allergies, Helicobacter pylori and the continental enigmas","volume":"6","author":"Sitaraman R","year":"2015","journal-title":"Front. 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