{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:55:21Z","timestamp":1789588521158,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Secretory carcinoma (SC) (synonym: mammary analogue secretory carcinoma) is a low\u2010grade salivary gland tumour that occurs in both major and minor salivary glands. SC is known for its wide morphological, architectural and immunohistochemical spectrum, which overlaps with those of several salivary gland neoplasms, including acinic cell carcinoma (AciCC) and intercalated duct\u2010type intraductal carcinoma (IDC) in major salivary glands, and polymorphous adenocarcinoma (PAC) in minor salivary glands. These tumours share with SC some morphological features and SOX10 immunoreactivity; also, with the exception of AciCC, they all coexpress S100 and mammaglobin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We compared MUC4 and mammaglobin expression in 125 salivary gland carcinomas (54 genetically confirmed SCs, 20 AciCCs, 21 PACs, and 30 IDCs) to evaluate the potential of these two markers to differentiate these entities. Moderate to strong diffuse MUC4 positivity was detected in 49 SCs (90.7%), as compared with none of the IDCs and PACs. In contrast, mammaglobin was frequently expressed in SCs (30 of 36 cases; 83.3%), IDCs (24\/28; 85.7%), and PACs (7\/19; 36.8%). Two of three high\u2010grade SCs lost MUC4 expression in the high\u2010grade tumour component. No significant correlation was found between MUC4 expression and the fusion variant in SC (<jats:italic>ETV6<\/jats:italic>\u2013<jats:italic>NTRK<\/jats:italic> versus non\u2010<jats:italic>ETV6<\/jats:italic>\u2013<jats:italic>NTRK<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of our study identify MUC4 as a sensitive (90.7%) and specific (100%) marker for SC, with high positive (100%) and negative (93.4%) predictive values. Thus, MUC4 may be used as a surrogate for SC in limited biopsy material and in cases with equivocal morphology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14251","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T18:29:22Z","timestamp":1600367362000},"page":"315-324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["MUC4 is a valuable marker for distinguishing secretory carcinoma of the salivary glands from its mimics"],"prefix":"10.1111","volume":"79","author":[{"given":"Cecilia","family":"Taverna","sequence":"first","affiliation":[{"name":"Institute of Pathology Friedrich\u2010Alexander\u2010University Erlangen\u2010N\u00fcrnberg University Hospital Erlangen Germany"},{"name":"Department of Laboratory Medicine Unit of Anatomical Pathology Pisa University Hospital Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Ban\u011bc\u030ckov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine in Plzen Charles University Plzen Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Lorenzon","sequence":"additional","affiliation":[{"name":"The Molecular Foundry Lawrence Berkeley National Laboratory Berkeley CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annarita","family":"Palomba","sequence":"additional","affiliation":[{"name":"Unit of Histopathology and Molecular Diagnostics Careggi University Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1332-5838","authenticated-orcid":false,"given":"Alessandro","family":"Franchi","sequence":"additional","affiliation":[{"name":"Department of Translational Research School of Medicine University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Skalova","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine in Plzen Charles University Plzen Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0445-8161","authenticated-orcid":false,"given":"Abbas","family":"Agaimy","sequence":"additional","affiliation":[{"name":"Institute of Pathology Friedrich\u2010Alexander\u2010University Erlangen\u2010N\u00fcrnberg University Hospital Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181d9efcc"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-013-0455-y"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318231542a"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000088"},{"key":"e_1_2_8_6_1","first-page":"9008","article-title":"Mammary analog secretory carcinoma of salivary gland with high\u2010grade histology arising in hard palate, report of a case and review of literature","volume":"7","author":"Luo W","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-014-1701-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2014.09.012"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000972"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001065"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-019-01074-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001535"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/0470860790.ch6"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089169708300301"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/08959374000140011101"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1309\/9R6673QEC06D86Y4"},{"key":"e_1_2_8_17_1","first-page":"641","article-title":"Heterogeneity of mucin gene expression in normal and neoplastic tissues","volume":"53","author":"Ho SB","year":"1993","journal-title":"Cancer Res."},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/41.10.8245407"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1251"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9390"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000155856.84553.c9"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1054\/tice.2000.0162"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.112575"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10387"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.014043"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-016-0735-4"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-009-0479-2"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.4081\/rt.2017.7162"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.07.008"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0000000000000322"},{"key":"e_1_2_8_31_1","doi-asserted-by":"crossref","unstructured":"AgaimyA T\u00f6gelL HallerF ZenkJ HornungJ M\u00e4rklB. YAP1\u2010NUTM1 gene fusion in porocarcinoma of the external auditory canal.Head Neck Pathol. 2020. E\u2010pub ahead of print 20 May.","DOI":"10.1007\/s12105-020-01173-9"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001048"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001301"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2017.07.017"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-014-0557-1"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5103496"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960901)78:5<958::AID-CNCR4>3.0.CO;2-8"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2018.11.003"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000128662.66321.be"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181a55c15"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2017.02.019"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-015-1786-8"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182841554"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1497023"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(91)90432-C"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2005.03.019"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100095062"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12491"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2013.06.010"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13845"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-019-02640-7"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13981"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001279"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.14251","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/his.14251","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.14251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T13:22:28Z","timestamp":1693315348000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.14251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,9]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/his.14251"],"URL":"https:\/\/doi.org\/10.1111\/his.14251","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,9]]},"assertion":[{"value":"2020-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}