{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:12:39Z","timestamp":1747185159460,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T00:00:00Z","timestamp":1605916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>We describe cytologic and immunohistologic findings in virus transport medium on cases under investigation of SARS\u2010CoV\u20102 infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cytologic findings in cases under investigation of SARS\u2010CoV\u20102 infection from one hundred consecutive nasopharyngeal swab were reviewed. Immunohistochemistry and SARSCoV\u20102 RT\u2010PCR determination were performed to detect virus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No viral inclusions were noted in squamous cells obtained from virus transport medium. Immunohistochemical study with monoclonal antibody against SARS\u2010CoV\u20102 viral nucleoprotein showed positivity in squamous cells. No positivity was present in others cellular components.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SARS\u2010CoV\u20102 predominantly localizes squamous cells in cytology samples of patients with RT\u2010PCR positive determination of SARSCoV\u20102. The results of the current study support the notion that the nasopharyngeal region is the anatomical station that SARS\u2010CoV\u20102 infects first, and the infection can lead to the migration of the virus into the lower airways.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14257","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T19:32:15Z","timestamp":1600975935000},"page":"586-592","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Liquid\u2010based cytological and immunohistochemical study of nasopharyngeal swab from persons under investigation for SARS\u2010CoV\u20102 infection"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8894-2312","authenticated-orcid":false,"given":"David","family":"Parada","sequence":"first","affiliation":[{"name":"Department of Pathology Hospital Universitari de Sant Joan Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili Facultat de Medicine Universitat Rovira i Virgili Reus Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla B","family":"Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitari de Sant Joan Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili Facultat de Medicine Universitat Rovira i Virgili Reus Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Gum\u00e0","sequence":"additional","affiliation":[{"name":"Department of Oncology Hospital Universitari de Sant Joan Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili Facultat de Medicine Universitat Rovira i Virgili Reus Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Guilarte","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitari de Sant Joan Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili Facultat de Medicine Universitat Rovira i Virgili Reus Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesc","family":"Riu","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitari de Sant Joan Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili Facultat de Medicine Universitat Rovira i Virgili Reus Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","unstructured":"World Health Organization.Novel Coronavirus (201\u2010nCoV). 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