{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:32:54Z","timestamp":1791340374636,"version":"4.3.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Renal changes in patients with myeloproliferative neoplasms (MPNs) or myelodysplastic syndrome (MDS)\/MPNs have been addressed by few, respectively no, reports. The aim of this study was to focus on a systematic evaluation of renal biopsies in patients with MPNs or MDS\/MPNs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The cohort comprised 29 patients (23 men) aged 67\u00a0\u00b1\u00a011\u00a0years (mean\u00a0\u00b1\u00a0standard deviation), diagnosed with chronic myeloid leukaemia (<jats:italic>n<\/jats:italic>\u00a0=\u00a05), polycythaemia vera (<jats:italic>n<\/jats:italic>\u00a0=\u00a09), primary myelofibrosis (<jats:italic>n<\/jats:italic>\u00a0=\u00a05), essential thrombocythaemia (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), or chronic myelomonocytic leukaemia (<jats:italic>n<\/jats:italic>\u00a0=\u00a04), as well as MPNs or MDS\/MPNs not otherwise specified (<jats:italic>n<\/jats:italic>\u00a0=\u00a04). Patients manifested with proteinuria (93%), partially in the nephrotic range (46%), haematuria (72%), and impaired kidney function (93%). The most prominent histological findings included double\u2010contoured glomerular basement membranes (71%), acute endothelial damage (68%), intracapillary platelet aggregation (62%), mesangiolysis (21%), thrombotic microangiopathy (24%), segmental glomerulosclerosis (66%), mesangial hypercellularity and sclerosis, extramedullary haematopoiesis (17%), and also IgA nephropathy (21%) and glomerulonephritis (GN) with features of infection\u2010related GN (21%). MPN and MDS\/MPN patients showed significantly more chronic changes than age\u2010matched and sex\u2010matched controls, including global and segmental glomerulosclerosis, mesangial sclerosis, and hypercellularity, whereas the extent of arteriosclerosis was comparable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MPN and MDS\/MPN patients show glomerular scarring that exceeds age\u2010related phenomena. Ongoing endothelial damage, growth factors released by platelets and deposition of immune complexes are probably the causative mechanisms. Early recognition of renal failure heralded by proteinuria and haematuria, and consequent control of risk factors for kidney failure, should be recommended for MPN and MDS\/MPN patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14282","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T08:27:03Z","timestamp":1603182423000},"page":"738-748","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Renal disease associated with myeloproliferative neoplasms and myelodysplastic syndrome\/myeloproliferative neoplasms"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9974-6683","authenticated-orcid":false,"given":"Maike","family":"B\u00fcttner\u2010Herold","sequence":"first","affiliation":[{"name":"Department of Nephropathology Institute of Pathology Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU) Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Sticht","sequence":"additional","affiliation":[{"name":"Centre of Medical Research University Medical Centre Mannheim University of Heidelberg Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Wiech","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Nephropathology Section University Hospital Hamburg Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7647-7265","authenticated-orcid":false,"given":"Stefan","family":"Porubsky","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Centre of the Johannes Guttenberg University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"World Health Organization classification of tumours of haematopoietic and lymphoid tissues, revised","author":"Swerdlow SH","year":"2017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2016.263"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2014.01.014"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000168720"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(99)70047-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/08860220903573286"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2015.117"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.147"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2013.04.014"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2017-223803"},{"key":"e_1_2_8_12_1","first-page":"70","article-title":"Nephrotic syndrome in primary myelofibrosis with renal extramedullary hematopoiesis and glomerulopathy in the JAK inhibitor era","volume":"5","author":"Del Sordo R","year":"2017","journal-title":"Clin. 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