{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:57:04Z","timestamp":1791309424807,"version":"4.3.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007914","name":"University of Texas Southwestern Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007914","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      Salivary gland intraductal carcinoma (IDC) is a complex ductal neoplasm surrounded by a layer of myoepithelial cells. Recent insights have shown that there are three different types: intercalated duct\u2010like, with frequent\n                      <jats:italic>NCOA4<\/jats:italic>\n                      \u2013\n                      <jats:italic>RET<\/jats:italic>\n                      fusions; apocrine, with salivary duct carcinoma\u2010like mutations; and mixed intercalated duct\u2010like\/apocrine, with\n                      <jats:italic>RET<\/jats:italic>\n                      fusions, including\n                      <jats:italic>TRIM27<\/jats:italic>\n                      \u2013\n                      <jats:italic>RET<\/jats:italic>\n                      . In addition, an oncocytic IDC has been described, but it remains unclear whether it represents a fourth variant or simply oncocytic metaplasia of another IDC type. Our aim was to more completely characterize oncocytic IDC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Six IDCs with oncocytic changes were retrieved from the authors\u2019 archives, from three men and three women ranging in age from 45 to 75\u00a0years (mean, 63\u00a0years). Five arose in the parotid gland, with one in an accessory parotid gland. Four patients with follow\u2010up were free of disease after 1\u201323\u00a0months. Several immunostains (S100, mammaglobin, androgen receptor, and p63\/p40) and molecular tools (RNA sequencing,\n                      <jats:italic>RET<\/jats:italic>\n                      fluorescence\n                      <jats:italic>in\u2010situ<\/jats:italic>\n                      hybridisation, BRAF V600E VE1 immunohistochemistry, and Sanger sequencing) were applied. Histologically, the tumours were variably cystic with solid intracystic nodules often difficult to recognise as intraductal. In all, tumour ducts were positive for S100 and mammaglobin, negative for androgen receptor, and completely surrounded by myoepithelial cells positive for p63\/p40. Molecular analysis revealed\n                      <jats:italic>TRIM33<\/jats:italic>\n                      \u2013\n                      <jats:italic>RET<\/jats:italic>\n                      in two of six cases,\n                      <jats:italic>NCOA4<\/jats:italic>\n                      \u2013\n                      <jats:italic>RET<\/jats:italic>\n                      in one of six cases, and\n                      <jats:italic>BRAF<\/jats:italic>\n                      V600E in two of six cases. One case had no identifiable alterations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Oncocytic IDC shares similarities with intercalated duct\u2010like IDC. Although additional verification is needed, the oncocytic variant appears to be sufficiently unique to be now regarded as the fourth distinct subtype of IDC. Because of its indolent nature, oncocytic IDC should be distinguished from histological mimics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.14296","type":"journal-article","created":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T23:52:56Z","timestamp":1604274776000},"page":"338-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Oncocytic intraductal carcinoma of salivary glands: a distinct variant with\n                    <i>TRIM33\u2013RET<\/i>\n                    fusions and\n                    <i>BRAF<\/i>\n                    V600E mutations"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0412-6810","authenticated-orcid":false,"given":"Justin A","family":"Bishop","sequence":"first","affiliation":[{"name":"Department of Pathology UT Southwestern Medical Center Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Nakaguro","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine Nagoya University Hospital Nagoya Japan"},{"name":"Department of Pathology Massachusetts General Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumeal D","family":"Whaley","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Juntendo University Nerima Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Imai","sequence":"additional","affiliation":[{"name":"Pathology Division Mie University Hospital Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9688-3167","authenticated-orcid":false,"given":"Israa","family":"Laklouk","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C","family":"Faquin","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M","family":"Sadow","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Gagan","sequence":"additional","affiliation":[{"name":"Department of Pathology UT Southwestern Medical Center Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitaka","family":"Nagao","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology Tokyo Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,31]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"170","volume-title":"Pathology and genetics of head and neck tumours. 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