{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T04:23:23Z","timestamp":1748319803679,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The diagnostic and clinical significance of granulomas in gastrointestinal (GI) biopsies from haematopoietic transplant patients remains disputed, especially following the proposal of cord colitis syndrome (CCS) as a new entity. The aim of the following study was to explore this controversy by identifying such biopsies with granulomas and detailing their clinicopathological associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Twelve patients with granuloma\u2010containing biopsies were identified from across three scenarios: prospectively during a GI pathologist\u2019s routine practice over a period of 5\u00a0years; retrospectively from a cohort of transplant patients with clinically validated GI graft versus host disease (GVHD); and retrospectively from a cohort of patients who had received umbilical cord blood (UCB). Their clinicopathological assessments (which included unique long\u2010term patient follow\u2010up) showed that granulomas are only rarely seen across all GI biopsies from haematopoietic transplant patients, and may uncommonly constitute a histological feature of GI GVHD. Granulomas\u2014and especially well\u2010defined, non\u2010cryptolytic ones\u2014are more commonly present in GI biopsies from UCB recipients, but do not show any accompanying histological features that are different from those seen in granuloma\u2010containing biopsies from other patient groups. Furthermore, the three UCB recipients with granuloma\u2010containing biopsies were clinically diagnosed with GVHD rather than CCS. Finally, polymorphic post\u2010transplant lymphoproliferative disorder (PTLD) can present histologically as GI granulomatous inflammation that mimics Crohn\u2019s disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Granulomas in GI biopsies of haematopoietic transplant patients may often indicate a treatable aetiology such as GVHD or PTLD. Granulomas are more commonly seen in GI biopsies from UCB recipients, but do not necessarily indicate a diagnosis of CCS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14303","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T06:42:12Z","timestamp":1605940932000},"page":"772-777","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The diagnostic and clinical significance of granulomas in gastrointestinal biopsies from haematopoietic transplant patients"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9537-4106","authenticated-orcid":false,"given":"Newton A C S","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Cellular Pathology Southmead Hospital UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David I","family":"Marks","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Unit University Hospitals Bristol NHS Trust Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12542"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1104959"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31828a827a"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.8948-17"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.03.020"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2013.44"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2019-206310"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-017-2210-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200203000-00005"},{"issue":"1","key":"e_1_2_7_11_1","first-page":"92","article-title":"Involvement of the gastrointestinal tract by Epstein\u2010Barr virus\u2010associated posttransplant lymphoproliferative disorders","volume":"14","author":"Nalesnik MA","year":"1990","journal-title":"Am. J. Surg. 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