{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:37:47Z","timestamp":1784763467464,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To characterise and compare the poorly understood clinicopathological and molecular characteristics of prostatic adenocarcinoma (PCa) in very young patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We compared the clinicopathological and molecular characteristics of PCa diagnosed in 90 patients aged \u226445\u00a0years with those of PCa diagnosed in 200 patients of typical screening age (i.e. 60\u201365\u00a0years). Patients diagnosed at a younger age had a higher frequency of a family history of PCa and lower prostate\u2010specific antigen (PSA) levels than those diagnosed at regular screening age. There were no statistically significant differences in clinical stage or pathological characteristics of the core biopsy specimens between the groups. Young patients had a higher frequency of Grade Group 1 disease at radical prostatectomy. A subset of 13 aggressive PCa cases from young patients underwent successful DNA\u2010based next\u2010generation sequencing. In all, 46.2% (6\/13) had <jats:italic>TMPRSS2<\/jats:italic> rearrangements and 23.1% (3\/13) had relevant pathogenic variants in DNA damage repair genes, including a mismatch repair\u2010deficient case with biallelic inactivation of <jats:italic>MLH1<\/jats:italic>. No statistically significant differences were observed in PCa\u2010specific recurrence\/progression between the younger and older patients, including after adjustment for clinical stage, PSA level, and Grade Group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study, the clinicopathological and molecular features of PCa diagnosed in young patients were comparable to those of PCa diagnosed in patients of screening age. Early\u2010onset PCa cases were not enriched in any of the known molecular PCa subtypes in this small series.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14315","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T16:30:16Z","timestamp":1607704216000},"page":"857-870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinicopathological and molecular characteristics of prostate cancer diagnosed in young men aged up to 45\u00a0years"],"prefix":"10.1111","volume":"78","author":[{"given":"Nicholas","family":"Baniak","sequence":"first","affiliation":[{"name":"Department of Pathology Genitourinary Pathology Division Brigham and Women\u2019s Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette M","family":"Sholl","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA USA"},{"name":"Department of Pathology Molecular Pathology Division (Center for Advanced Molecular Diagnostics) Brigham and Women\u2019s Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A","family":"Mata","sequence":"additional","affiliation":[{"name":"Foundation Medicine, Inc. 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