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The difficulties in diagnosing PA arise from its ability to mimic invasion, show atypical or metaplastic cytomorphology, and show morphological features that overlap with those of established salivary gland carcinomas. In addition, recognising early malignant transformation to carcinoma ex\u2010pleomorphic adenoma continues to be a frequent challenge. This review describes the diagnostic pitfalls of PA, and offers a systematic approach to avoid them by combining classic histopathology with novel immunohistochemical and molecular tests.<\/jats:p>","DOI":"10.1111\/his.14322","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T07:05:31Z","timestamp":1609139131000},"page":"279-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Pleomorphic adenoma: the great mimicker of malignancy"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0809-4649","authenticated-orcid":false,"given":"Juan C","family":"Hernandez\u2010Prera","sequence":"first","affiliation":[{"name":"Department of Pathology Moffitt Cancer Center Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Sk\u00e1lov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine in Plzen Charles University Plzen Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1332-5838","authenticated-orcid":false,"given":"Alessandro","family":"Franchi","sequence":"additional","affiliation":[{"name":"Department of Translational Research and of New Technologies in Medicine and Surgery University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Rinaldo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Udine Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Vander Poorten","sequence":"additional","affiliation":[{"name":"Department of Oncology Section\u00a0Head and Neck Oncology KU Leuven Leuven Belgium"},{"name":"Otorhinolaryngology\u2013Head and Neck Surgery Leuven Cancer Institute University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Zb\u00e4ren","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery University Hospital Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfio","family":"Ferlito","sequence":"additional","affiliation":[{"name":"International Head and Neck Scientific Group Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce M","family":"Wenig","sequence":"additional","affiliation":[{"name":"Department of Pathology Moffitt Cancer Center Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70323-2"},{"key":"e_1_2_10_3_1","volume-title":"World Health Organization classification of head and neck tumours","author":"El\u2010Naggar AK","year":"2017"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197106)27:6<1415::AID-CNCR2820270622>3.0.CO;2-X"},{"key":"e_1_2_10_5_1","first-page":"271","article-title":"Mixed tumors of the salivary glands. 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