{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:40:39Z","timestamp":1761766839063,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Hepatocellular adenoma (HCA) is an uncommon liver neoplasm, and studies of HCA subtypes have been primarily limited to France, the USA, and Japan. The aim of this study was to describe the clinicopathological features of HCA subtypes in Turkey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The resection specimens of 59 cases diagnosed as \u2018hepatocellular adenoma\u2019 collected from 15 institutions were reviewed to confirm the diagnosis and to classify them according to the current World Health Organization 2019 classification. Immunostaining for glutamine synthetase, liver fatty acid\u2010binding protein, C\u2010reactive protein, \u03b2\u2010catenin and reticulin was performed. Of the 59 cases, 48 (81%) were diagnosed as HCA. We identified 24 (50%) hepatocyte nuclear factor 1\u03b1 (HNF1\u03b1)\u2010inactivated HCAs, five (10%) inflammatory HCAs, 15 (32%) \u03b2\u2010catenin\u2010activated HCAs, three (6%) \u03b2\u2010catenin\u2010activated inflammatory HCAs, and one (2%) unclassified HCA. HCA patients were predominantly female (female\/male ratio of 5:1); they had a median age of 34\u00a0years and a median tumour diameter of 60\u00a0mm. In the \u03b2\u2010catenin\u2010activated HCA group, nine cases (19%) showed cytoarchitectural atypia, and were also referred to as atypical hepatocellular neoplasms. In the \u03b2\u2010catenin\u2010activated HCA group, three cases (6%) showed focal areas supportive of transition to HCA. The original diagnosis of HCA was changed to well\u2010differentiated hepatocellular carcinoma in nine cases and to focal nodular hyperplasia in two cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our series, the major HCA subtype was HNF1\u03b1\u2010inactivated HCA. We found a low incidence of inflammatory\u2010type HCA. Our data also showed that \u03b2\u2010catenin\u2010activated hepatocellular neoplasms, including cases with atypical histology, constituted a relatively high proportion of the cases. These findings are in contrast to those of most other studies of HCA subtypes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14330","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T14:00:11Z","timestamp":1610114411000},"page":"23-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hepatocellular adenomas in the Turkish population: reclassification according to updated World Health Organization criteria"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7749-2152","authenticated-orcid":false,"given":"Kemal","family":"Deniz","sequence":"first","affiliation":[{"name":"Department of Pathology Erciyes University Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2175-0671","authenticated-orcid":false,"given":"Sarah E","family":"Umetsu","sequence":"additional","affiliation":[{"name":"Department 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