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The UIP pattern is also found in pulmonary fibrosis attributable to clinical diagnoses other than IPF (non\u2010IPF UIP), whose clinical course is similarly poor, suggesting common molecular drivers. This study investigates whether IPF and non\u2010IPF UIP lungs similarly express markers of telomere dysfunction and senescence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>To test whether patients with IPF and non\u2010IPF UIP share molecular drivers, lung tissues from 169 IPF patients and 57 non\u2010IPF UIP patients were histopathologically and molecularly compared. Histopathological changes in both IPF and non\u2010IPF UIP patients included temporal heterogeneity, microscopic honeycombing, fibroblast foci, and dense collagen fibrosis. Non\u2010IPF UIP lungs were more likely to have lymphocytic infiltration, non\u2010caseating granulomas, airway\u2010centred inflammation, or small airways disease. Telomeres were shorter in alveolar type II (AECII) cells of both IPF and non\u2010IPF UIP lungs than in those of age\u2010similar, unused donor, controls. Levels of molecular markers of senescence (p16 and p21) were elevated in lysates of IPF and non\u2010IPF UIP lungs. Immunostaining localised expression of these proteins to AECII cells. The mucin 5B (MUC5B) gene promoter variant minor allele frequency was similar between IPF and non\u2010IPF UIP patients, and MUC5B expression was similar in IPF and non\u2010IPF UIP lungs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Molecular markers of telomere dysfunction and senescence are pathologically expressed in both IPF and non\u2010IPF UIP lungs. These findings suggest that common molecular drivers may contribute to the pathogenesis of UIP\u2010associated pulmonary fibrosis, regardless of the clinical diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14334","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T07:05:29Z","timestamp":1610694329000},"page":"67-76","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Molecular markers of telomere dysfunction and senescence are common findings in the usual interstitial pneumonia pattern of lung fibrosis"],"prefix":"10.1111","volume":"79","author":[{"given":"Joyce S","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Pulmonary Sciences and Critical Care Medicine University of Colorado Denver CO 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