{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:00:26Z","timestamp":1792519226117,"version":"4.5.0"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T00:00:00Z","timestamp":1623542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>\n                    Breast lesions with a prominent myoepithelial cell component constitute a heterogeneous group of benign and malignant neoplastic proliferations. These lesions are often dual epithelial\u2013myoepithelial, but may be purely myoepithelial cell in nature. Benign epithelial\u2013myoepithelial lesions typically maintain the morphology and immunophenotype of the normal bilayer epithelial myoepithelial structures. However, the distinction between the two cell components is not always clear\u2010cut in malignant lesions in which the histogenesis of myoepithelial cells remains uncertain. Neoplastic biphasic epithelial\u2013myoepithelial lesions of the breast include adenomyoepithelioma (AME), pleomorphic adenoma and adenoid cystic carcinoma. Four histological patterns of classical AME have been described: tubular, lobulated, spindle\u2010cell and adenosis variants. Overlapping patterns occur and some AMEs display an intraductal papillary pattern that may represent a fifth variant. AME can be benign or malignant. Classical AME may show atypical features, which are not sufficient for the diagnosis of malignancy (atypical AME). Atypical AME is recognised as a lesion of uncertain malignant potential with limited metastatic capability. Based on the histological features, we propose a classification of malignant AME (M\u2010AME) into three variants: M\u2010AME\n                    <jats:italic>in\u00a0situ<\/jats:italic>\n                    , M\u2010AME invasive and AME with invasive carcinoma. In this review, we provide an overview of myoepithelial lesions of the breast focusing on the classification of AME to improve not only the consistency of reporting but also help to guide further management decision\u2010making.\n                  <\/jats:p>","DOI":"10.1111\/his.14380","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T02:35:42Z","timestamp":1617849342000},"page":"465-479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Adenomyoepithelioma of the breast: a proposal for classification"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5009-5525","authenticated-orcid":false,"given":"Emad","family":"Rakha","sequence":"first","affiliation":[{"name":"Department of Histopathology University of Nottingham and Nottingham University Hospital NHS Trust Nottingham City Hospital Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puay Hoon","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Pathology Singapore General Hospital Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Histopathology University of Nottingham and Nottingham University Hospital NHS Trust Nottingham City Hospital Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecily","family":"Quinn","sequence":"additional","affiliation":[{"name":"Department of Histopathology St Vincent\u2019s University Hospital University College Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10911-005-9586-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02532"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13446"},{"key":"e_1_2_8_5_1","first-page":"39","volume-title":"WHO classification of tumours","author":"Tan PH","year":"2019"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2016.10.011"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-5-92"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-014-1687-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2012.02982.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04128-5"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-018-0101-7"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.07.010"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199106000-00004"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2016.808"},{"key":"e_1_2_8_15_1","first-page":"2654","article-title":"Malignant myoepithelioma of the breast: a case report and review of literature","volume":"7","author":"Liang YF","year":"2014","journal-title":"Int. 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