{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:08:53Z","timestamp":1781154533974,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR062080"],"award-info":[{"award-number":["R01AR062080"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","award":["2018042"],"award-info":[{"award-number":["2018042"]}],"id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005345","name":"American Association for Dental Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004368","name":"Colgate-Palmolive Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Fibrous cephalic plaques (FCPs) in individuals with tuberous sclerosis complex (TSC) may be excised for cosmetic reasons or biopsied to confirm lesion identification and TSC diagnosis. The aim of this study was to determine the range of histopathological features of FCPs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A retrospective analysis was conducted on 119 adults with TSC. Twenty\u2010one lesions from 16 individuals were evaluated by a dermatopathologist. Additionally, we assessed whether lesion colour or histology varied by anatomical location. Seventy\u2010six lesions were observed in 36 of 119 individuals. Erythematous lesions were more commonly found on the forehead, face or neck than on the scalp (odds ratio\u00a0=\u00a012.6, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001). Thickened and disorganised collagen fibre bundles were present in 95% (20\/21) of lesions. Perifollicular fibrosis was observed in 95% (20\/21) of lesions, enhanced vascularity was observed in 52% (11\/21) of lesions, and features of fibrofolliculoma were observed in 43% (9\/21) of lesions. Other abnormalities included features similar to trichofolliculoma, follicular\u2010derived, infundibular\u2010type cysts, and abnormally arranged primitive hair follicles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FCPs in TSC show thickened bundles of collagen, and hamartomatous changes involving hair follicles. Recognition of these histopathological features may raise the possibility of unsuspected TSC or confirm FCP identification.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14392","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T05:39:24Z","timestamp":1619069964000},"page":"619-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Histopathological features of fibrous cephalic plaques in tuberous sclerosis complex"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4609-9395","authenticated-orcid":false,"given":"Alison M","family":"Treichel","sequence":"first","affiliation":[{"name":"Pulmonary Branch National Heart, Lung, and Blood Institute National Institutes of Health Bethesda MD USA"},{"name":"Department of Dermatology Uniformed Services University of the Health Sciences Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deeti J","family":"Pithadia","sequence":"additional","affiliation":[{"name":"Pulmonary Branch National Heart, Lung, and Blood Institute National Institutes of Health Bethesda MD USA"},{"name":"Department of Dermatology Uniformed Services University of the Health Sciences Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chyi\u2010Chia R","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyetewa","family":"Oyerinde","sequence":"additional","affiliation":[{"name":"Pulmonary Branch National Heart, Lung, and Blood Institute National Institutes of Health Bethesda MD USA"},{"name":"Department of Dermatology Uniformed Services University of the Health Sciences Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Moss","sequence":"additional","affiliation":[{"name":"Pulmonary Branch National Heart, Lung, and Blood Institute National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas N","family":"Darling","sequence":"additional","affiliation":[{"name":"Department of Dermatology Uniformed Services University of the Health Sciences Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,21]]},"reference":[{"issue":"49","key":"e_1_2_9_2_1","first-page":"243","article-title":"International Tuberous Sclerosis Complex Consensus Conference","volume":"2013","author":"Northrup H","year":"2012","journal-title":"Pediatr. 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