{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:30:15Z","timestamp":1787682615086,"version":"build-2784847793"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Appendiceal orifice mucosa often appears inflamed endoscopically, even when other colonic segments appear normal. Histological findings in biopsy samples taken from endoscopically abnormal mucosa may simulate a variety of inflammatory colitides. We performed this study to evaluate the clinical implications of inflammatory changes isolated to the appendiceal orifice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>In this double cohort study, biopsy samples from 26 histologically abnormal appendiceal orifices were reviewed. Twenty\u2010five control cases were culled from endoscopically normal (<jats:italic>n<\/jats:italic>\u00a0=\u00a011) and abnormal (<jats:italic>n<\/jats:italic>\u00a0=\u00a014) appendiceal orifices that were histologically normal. Histological findings were correlated with presentation, medication history, findings at other colonic sites and clinical outcomes. Study cases displayed active inflammation (<jats:italic>n<\/jats:italic>\u00a0=\u00a012), chronic active inflammation (<jats:italic>n<\/jats:italic>\u00a0=\u00a013) or features simulating collagenous colitis (<jats:italic>n<\/jats:italic>\u00a0=\u00a01). Eighteen patients had biopsies taken from other colonic sites; these revealed benign polyps (<jats:italic>n<\/jats:italic>\u00a0=\u00a010) or displayed active (<jats:italic>n<\/jats:italic>\u00a0=\u00a04) or chronic active (<jats:italic>n<\/jats:italic>\u00a0=\u00a04) inflammation. All patients with findings isolated to the appendiceal orifice were asymptomatic at most recent clinical follow\u2010up. Four of eight (50%) of the patients with inflammation in other biopsy samples were ultimately diagnosed with ulcerative colitis, in keeping with the well\u2010established role of the appendix as a \u2018skip lesion\u2019 in that disorder. Control patients presented for screening colonoscopy (<jats:italic>n<\/jats:italic>\u00a0=\u00a019), iron deficiency anaemia (<jats:italic>n<\/jats:italic>\u00a0=\u00a03) or change in bowel habits (<jats:italic>n<\/jats:italic>\u00a0=\u00a03) and none reported gastrointestinal symptoms upon follow\u2010up, regardless of the endoscopic appearance of the appendiceal orifice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Isolated inflammation of the appendiceal orifice mucosa should not be regarded as a feature of evolving inflammatory bowel disease or other types of chronic colitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14418","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T08:34:40Z","timestamp":1621499680000},"page":"751-757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical significance of pathologic abnormalities in biopsy samples from the appendiceal orifice"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3090-7108","authenticated-orcid":false,"given":"Carlos A.","family":"Castrodad\u2010Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Department of Pathology Montefiore Medical Center Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jui","family":"Choudhuri","sequence":"additional","affiliation":[{"name":"Department of Pathology Montefiore Medical Center Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"El\u2010Jabbour","sequence":"additional","affiliation":[{"name":"Department of Pathology Montefiore Medical Center Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Medical School Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Westerhoff","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Medical School Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1121-267X","authenticated-orcid":false,"given":"Nicole C.","family":"Panarelli","sequence":"additional","affiliation":[{"name":"Department of Pathology Montefiore Medical Center Albert Einstein College of Medicine Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/849892"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i34.5398"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1990.tb01069.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510023305"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12821"},{"key":"e_1_2_7_7_1","first-page":"912","article-title":"Appendiceal involvement as a skip lesion in ulcerative colitis","volume":"7","author":"Kroft SH","year":"1994","journal-title":"Mod. Pathol."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1998.00477.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-255X(99)80023-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655202753416849"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2002.121335"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MIB.0000164018.06538.6e"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1424-x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1291443"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2019-206146"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198209000-00004"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/110.5.622"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2007.01.014"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012-0205-RA"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2018.4373"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.14418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/his.14418","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.14418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T23:32:00Z","timestamp":1693351920000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.14418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,6]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/his.14418"],"URL":"https:\/\/doi.org\/10.1111\/his.14418","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,6]]},"assertion":[{"value":"2021-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}