{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T15:04:42Z","timestamp":1787151882813,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T00:00:00Z","timestamp":1631404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Little is known regarding the histopathological and molecular features of lung adenocarcinoma skin metastases. Our study is the largest, to our knowledge, to comprehensively explore these to date.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We performed a retrospective cohort study analysing 42 lung adenocarcinoma skin metastasis samples obtained from a database of 2659 lung adenocarcinomas collected between 2010 and 2020. <jats:italic>EGFR<\/jats:italic> exon 19 deletion was detected in one patient and <jats:italic>KRAS<\/jats:italic> mutations were detected in 12 (33.3%) patients. The programmed cell death ligand 1 (PD\u2010L1) tumour proportion score was &lt;1% in 27 patients, \u22651% and &lt;50% in eight patients, \u226550% in six patients and not assessable in one patient. We showed that the predominant histopathological subtype is different from that at other metastatic sites (<jats:italic>P<\/jats:italic>\u2009=\u20090.024). Thyroid transcription factor I (TTF\u20101) was more often negative in skin metastases compared to other sites (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The <jats:italic>EGFR<\/jats:italic> mutation rate tended to be lower for skin metastases compared to other sites (<jats:italic>P<\/jats:italic>\u2009=\u20090.079). Skin metastases were associated with a high rate of PD\u2010L1\u2010negative cases (<jats:italic>P<\/jats:italic>\u2009=\u20090.022).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our work shows that the skin metastases of lung adenocarcinoma have a specific histopathological profile.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14463","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T09:30:32Z","timestamp":1627378232000},"page":"1051-1060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Histopathological and molecular profiling of lung adenocarcinoma skin metastases reveals specific features"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7582-3923","authenticated-orcid":false,"given":"Fabien","family":"Forest","sequence":"first","affiliation":[{"name":"Department of Pathology University Hospital of Saint Etienne 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