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Head and neck (46.2%) were most commonly involved. The median age was 53\u2009years, with a male predilection. Histologically, tumours were classified as grades 1 (eight), 2 (four) and 3 with high\u2010grade transformation (HGT) (one). The HGT component was demonstrated as poorly differentiated carcinoma with multifocal necrosis and myoepithelial differentiation. Patients with one of the following factors: longest diameter of the lesion (\u2265\u20091\u2009cm), involvement of subcutaneous fat tissue and widely infiltrative border had a relatively higher rate of local recurrence, distant metastasis and death. Five of six cases were confirmed to have <jats:italic>MYB<\/jats:italic> translocation, while nuclear staining for MYB proto\u2010oncogene, transcription factor (MYB) protein was found in four cases. During the follow\u2010up (median\u2009=\u200964\u2009months), two patients experienced local recurrences. One patient, who was classified as grade III PCACC with HGT, developed multiple metastases and died of disease. Another patient was alive with multiple metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the largest single\u2010institution study, to our knowledge, of PCACC in an Asian population. We describe the first case of scalp PCACC with HGT, which is the only death case in our series. PCACC tends to recur locally and has metastatic potential. PCACC with HGT has a poor prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14565","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T02:41:30Z","timestamp":1631587290000},"page":"407-419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Primary cutaneous adenoid cystic carcinoma: a clinicopathologic, immunohistochemical, and fluorescence <i>in\u2010situ<\/i> hybridisation study of 13 cases"],"prefix":"10.1111","volume":"80","author":[{"given":"Jiao\u2010Jie","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Pathology Fudan University Shanghai Cancer Center Shanghai China"},{"name":"Department of Oncology Shanghai Medical College Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Pathology Fudan University Shanghai Cancer Center 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