{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:23:54Z","timestamp":1792106634474,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K08648"],"award-info":[{"award-number":["19K08648"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K08925"],"award-info":[{"award-number":["20K08925"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Idiopathic pleuroparenchymal fibroelastosis (PPFE) is a rare type of idiopathic interstitial pneumonia, and pathological PPFE is also observed in patients with secondary interstitial pneumonia. This study aimed to evaluate the pathological findings associated with radiological PPFE\u2010like lesions and the clinical and morphological features of patients with pathological PPFE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We retrospectively reviewed the pathology of the explanted lungs from 59 lung transplant recipients with radiological PPFE\u2010like lesions. Pathological PPFE lesions were identified in 14 patients with idiopathic disease and in 12 patients with secondary disease. Pathological PPFE was associated with previous pneumothorax, volume loss in the upper lobes, and a flattened chest. Patients with idiopathic disease and those with secondary disease with pathological PPFE had similar clinical, radiological and pathological findings, whereas fibroblastic foci were more common in patients with idiopathic disease, and patients with secondary disease more frequently showed alveolar septal thickening with elastosis or fibrosis. Post\u2010transplantation survival did not differ between patients with idiopathic and secondary disease with pathological PPFE (log\u2010rank; <jats:italic>P<\/jats:italic>\u2009=\u20090.57) and was similar between patients with idiopathic disease with pathological PPFE and those with idiopathic pulmonary fibrosis (IPF) (log\u2010rank; <jats:italic>P<\/jats:italic>\u2009=\u20090.62).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Not all patients with interstitial pneumonia with radiological PPFE\u2010like lesions have pathological PPFE. Characteristic clinical features can suggest the presence of pathological PPFE, and idiopathic and secondary cases with pathological PPFE are similar except for fibroblastic foci in idiopathic cases and alveolar septal thickening with elastosis or fibrosis in secondary cases. Patients with pathological PPFE have a similar prognosis to those with IPF after transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14595","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T12:18:03Z","timestamp":1636373883000},"page":"665-676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical, radiological and pathological features of idiopathic and secondary interstitial pneumonia with pleuroparenchymal fibroelastosis in patients undergoing lung transplantation"],"prefix":"10.1111","volume":"80","author":[{"given":"Naoya","family":"Ikegami","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1462-7341","authenticated-orcid":false,"given":"Akihiko","family":"Yoshizawa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3378-6412","authenticated-orcid":false,"given":"Tomohiro","family":"Handa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine Kyoto University Kyoto Japan"},{"name":"Department of Advanced Medicine for Respiratory Failure Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyofumi","family":"Chen\u2010Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Graduate School of Medicine Kyoto University Kyoto Japan"},{"name":"Department of Thoracic Surgery Graduate School of Medicine Nagoya University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kubo","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Nuclear Medicine Graduate School of Medicine Kyoto University Kyoto Japan"},{"name":"Department of Radiology Tenri Hospital Tenri Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiminobu","family":"Tanizawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Ohsumi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatsugu","family":"Hamaji","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yojiro","family":"Yutaka","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satona","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kizuku","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine Kyoto University Kyoto Japan"},{"name":"Department of Respiratory Medicine Japanese Red Cross Wakayama Medical Centre Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinari","family":"Nakatsuka","sequence":"additional","affiliation":[{"name":"Department of Respiratory Care and Sleep Control Medicine Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Murase","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9510-5646","authenticated-orcid":false,"given":"Tomoko","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine Kyoto University Kyoto Japan"},{"name":"Kyoto\u2013McGill International Collaborative School in Genomic Medicine Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Niwamoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Respiratory Care and Sleep Control Medicine Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Date","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyohiro","family":"Hirai","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,5]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"693","article-title":"[Idiopathic pulmonary upper lobe fibrosis (IPUF)]","volume":"11","author":"Amitani R","year":"1992","journal-title":"Kokyu"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1483ST"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00165111"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-2866"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00214714"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2018.06.022"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejro.2020.100298"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896917739399"},{"key":"e_1_2_9_10_1","first-page":"492","article-title":"A case of repeated bilateral pneumothorax associated with upper lobe predominant fibrosis in an aluminum processing worker","volume":"48","author":"Inuzuka K","year":"2010","journal-title":"Nihon Kokyuki Gakkai Zasshi"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2018.03.031"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12553"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13697"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00214713"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2004.08.026"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02135-2019"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180283"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0860-6"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejro.2020.100296"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201902-181CME"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.07.045"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.07.056"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2018.04.071"},{"key":"e_1_2_9_24_1","first-page":"291","article-title":"The pathogenesis and pathology of idiopathic pleuroparenchymal fibroelastosis","volume":"36","author":"Kinoshita Y","year":"2021","journal-title":"Histol. Histopathol."},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201807-1255ST"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00006713"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2014.10.007"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13171"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2019.02.007"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9113761"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10040846"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000928"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12833"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02243-2018"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2019.04.035"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-021-02232-6"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-021-06118-8"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10050957"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202005-2032ST"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.14595","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/his.14595","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.14595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T04:48:27Z","timestamp":1729486107000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.14595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,5]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/his.14595"],"URL":"https:\/\/doi.org\/10.1111\/his.14595","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,5]]},"assertion":[{"value":"2021-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}