{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:15:06Z","timestamp":1778796906071,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C8333\/A29707"],"award-info":[{"award-number":["C8333\/A29707"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Angioimmunoblastic T\u2010cell lymphoma (AITL) is genetically characterized by <jats:italic>TET2<\/jats:italic> and <jats:italic>DNMT3A<\/jats:italic> mutations occurring in haematopoietic progenitor cells, and late events (e.g. the <jats:italic>RHOA<\/jats:italic>\u2010G17V mutation) associated with malignant transformation. As <jats:italic>TET2<\/jats:italic>\/<jats:italic>DNMT3A<\/jats:italic>\u2010mutated progenitor cells can differentiate into multilineage progenies and give rise to both AITL and myeloid neoplasms, they may also have the potential to lead to other metachronous\/synchronous neoplasms. We report two cases showing parallel evolution of two distinct potentially neoplastic lymphoid proliferations from a common mutated haematopoietic progenitor cell population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Both cases presented with generalized lymphadenopathy. In case 1 (a 67\u2010year\u2010old female), an initial lymph node (LN) biopsy was dismissed as reactive, but a repeat biopsy showed a nodal marginal zone lymphoma (NMZL)\u2010like proliferation with an increase in the number of T\u2010follicular helper (TFH) cells. Immunohistochemistry, and clonality and mutational analyses by targeted sequencing of both whole tissue sections and microdissected NMZL\u2010like lesions, demonstrated a clonal B\u2010cell proliferation that harboured the <jats:italic>BRAF<\/jats:italic>\u2010G469R mutation and shared <jats:italic>TET2<\/jats:italic> and <jats:italic>DNMT3A<\/jats:italic> mutations with an underlying <jats:italic>RHOA\u2010<\/jats:italic>G17V\u2010mutant TFH proliferation. Review of the original LN biopsy showed histological and immunophenotypic features of AITL. In case 2 (a 66\u2010year\u2010old male), cytotoxic T\u2010cell lymphoma with an increase in the number of Epstein\u2013Barr virus\u2010positive large B cells was diagnosed on initial biopsy. On review together with the relapsed biopsy, we identified an additional occult neoplastic TFH proliferation\/smouldering AITL. Both T\u2010cell proliferations shared <jats:italic>TET2<\/jats:italic> and <jats:italic>DNMT3A<\/jats:italic> mutations while <jats:italic>RHOA<\/jats:italic>\u2010G17V was confined to the smouldering AITL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In addition to demonstrating diagnostic challenges, these cases expand the potential of clonal haematopoiesis in the development of different lineage neoplastic proliferations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14619","type":"journal-article","created":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T14:03:32Z","timestamp":1642860212000},"page":"847-858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Parallel evolution of two distinct lymphoid proliferations in clonal haematopoiesis"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5034-8150","authenticated-orcid":false,"given":"Ayoma 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