{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:23:42Z","timestamp":1791429822431,"version":"4.3.3"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Formal depiction of granulomatous inflammation associated with renal neoplasms has mainly consisted of case reports. Herein, we investigate the clinicopathological features and potential significance of granulomas associated with renal tumours from a large multi\u2010institutional cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>One hundred and eleven study cases were collected from 22 institutions, including 57 partial nephrectomies and 54 radical nephrectomies. Patient ages ranged from 27 to 85\u2009years (average\u2009=\u200960.1\u2009years; male\u2009=\u200961%). Renal neoplasms included clear cell renal cell carcinoma (RCC; 86%), papillary RCC (8%), chromophobe RCC (3%), clear cell papillary RCC (1%), mixed epithelial stromal tumour (1%) and oncocytoma (1%). Granulomas were peritumoral in 36%, intratumoral in 24% and\u2009both in 40% of cases. Total granuloma count per case ranged from one to 300 (median\u2009=\u200915) with\u2009sizes ranging from 0.15 to 15\u2009mm (mean\u2009= 1.9\u2009mm). Necrotising granulomas were seen in 14%\u2009of cases. Histochemical stains for organisms were performed on 45% of cases (all negative). Sixteen cases (14%) had a prior biopsy\/procedure performed, and eight patients had neoadjuvant immunotherapy or chemotherapy. Eleven patients (10%) had a confirmed diagnosis of sarcoidosis, including five in whom sarcoidosis was diagnosed after nephrectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on this largest case\u2010series to date, peri\u2212\/intratumoral granulomas associated with renal neoplasms may be more common than initially perceived. The extent of granulomatous inflammation can vary widely and may or may not have necrosis with possible aetiologies, including prior procedure or immunotherapy\/chemotherapy.\u2009Although a clinical association with sarcoidosis\u2009is infrequent it can still occur, and the presence of granulomas warrants mention in pathology reports.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14633","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T08:11:36Z","timestamp":1648541496000},"page":"922-927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Granulomas associated with renal neoplasms: A multi\u2010institutional clinicopathological study of 111 cases"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0874-8964","authenticated-orcid":false,"given":"Ankur R","family":"Sangoi","sequence":"first","affiliation":[{"name":"El Camino Hospital, Pathology Mountain View CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Maclean","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Douglass Hanly Moir Pathology, Sonic Healthcare Macquarie Park Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sambit","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Advanced Medical Research Institute Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3236-3127","authenticated-orcid":false,"given":"Ondrej","family":"Hes","sequence":"additional","affiliation":[{"name":"Department of Pathology Charles University Hospital and Medical Facility Plzen Plzen Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reba","family":"Daniel","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priti","family":"Lal","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Canete\u2010Portillo","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Magi\u2010Galluzzi","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine M","family":"Cornejo","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital and Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Collins","sequence":"additional","affiliation":[{"name":"Indiana University, Pathology Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hwang","sequence":"additional","affiliation":[{"name":"Indiana University, Pathology Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara M","family":"Falzarano","sequence":"additional","affiliation":[{"name":"Department of Pathology, Immunology and Laboratory Medicine University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike M","family":"Feely","sequence":"additional","affiliation":[{"name":"Department of Pathology, Immunology and Laboratory Medicine University of Florida Gainesville FL 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Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanika","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Pathology Henry Ford Hospital Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guliz","family":"Barkan","sequence":"additional","affiliation":[{"name":"Loyola University Healthcare Center Department of Pathology Maywood IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6049-5293","authenticated-orcid":false,"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Indiana University, Pathology Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital Harvard Medical School Boston MA 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