{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:25:54Z","timestamp":1790886354417,"version":"4.1.0"},"reference-count":125,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T00:00:00Z","timestamp":1652832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>Mesonephric lesions in the female genital tract are uncommon, with those arising from the upper tract being much less frequent than those developing in the lower tract (mesonephric hyperplasia and carcinoma). The most common upper tract lesions include rete cyst\/cystadenoma and female adnexal tumour of Wolffian origin (FATWO). The integration of morphological, immunohistochemical and molecular studies on FATWOs has enabled recognition of a novel entity, the <jats:italic>STK11<\/jats:italic> adnexal tumour, which is often associated with Peutz\u2013Jeghers syndrome (~50%) and frequently has a salivary gland morphology but an unknown origin. Similarly, \u2018mesonephric\u2010like\u2019 adenocarcinoma, an entity with striking similarities to mesonephric carcinoma but currently favoured to be of M\u00fcllerian derivation based on its association with other M\u00fcllerian tumours and molecular findings, has also been recently described, and may histologically mimic both FATWOs and <jats:italic>STK11<\/jats:italic> adnexal tumours. In this review, we provide a historical overview of upper female genital tract mesonephric proliferations and discuss mesonephric lesions, <jats:italic>STK11<\/jats:italic> adnexal tumour, mesonephric\u2010like adenocarcinoma, and mimickers, the most common being endometrioid carcinoma.<\/jats:p>","DOI":"10.1111\/his.14662","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T17:54:48Z","timestamp":1649440488000},"page":"280-296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The complex and often confusing history, histology and histogenesis of mesonephric, <scp><i>STK11<\/i><\/scp> adnexal tumour and <scp>mesonephric\u2010like<\/scp> neoplasms of the upper female genital tract (including broad ligament)"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8155-7131","authenticated-orcid":false,"given":"J A","family":"Bennett","sequence":"first","affiliation":[{"name":"Department of Pathology University of Chicago Medicine  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Oliva","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199810000-00015"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31827ddd42"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000371"},{"key":"e_1_2_11_5_1","first-page":"1","article-title":"Mesonephroma ovarii","volume":"35","author":"Schiller W","year":"1939","journal-title":"Am. J. Cancer"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195911\/12)12:6<1092::AID-CNCR2820120606>3.0.CO;2-V"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896914558265"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196709)20:9<1405::AID-CNCR2820200907>3.0.CO;2-B"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(48)90570-5"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(48)90188-4"},{"key":"e_1_2_11_11_1","first-page":"264","article-title":"Mesonephric remnants in the adult female","volume":"8","author":"Bisca BV","year":"1956","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197303)31:3<671::AID-CNCR2820310328>3.0.CO;2-K"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(65)90088-8"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(57)90014-5"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90148-X"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000545"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0375-9"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198303000-00002"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.35.5.526"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199204000-00006"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12895"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000958"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001401"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001612"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00799-6"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001677"},{"key":"e_1_2_11_27_1","volume-title":"Gray's anatomy: The anatomical basis of clinical practice","author":"Collins P","year":"2015"},{"key":"e_1_2_11_28_1","volume-title":"Surgical techniques in pediatric and adolescent urology","author":"Kuhn C","year":"2019"},{"key":"e_1_2_11_29_1","volume-title":"Histology for pathologists","author":"Atkins KA","year":"2019"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-6053(00)80005-8"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2017.11.084"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000333"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896919851209"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-198812000-00004"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/003130200104277"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00938.x"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200103000-00013"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2001.01086.x"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200302000-00005"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2003.01684.x"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001142"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-200110000-00006"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000102"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000471"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000326"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)91207-S"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000155160.36154.mL"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.04151.x"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000666"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(97)90235-5"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.0855f.x"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2020-0432-OA"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1995.0027"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850915)56:6<1456::AID-CNCR2820560638>3.0.CO;2-Z"},{"key":"e_1_2_11_55_1","first-page":"310","article-title":"Malignant female adnexal tumor of probable Wolffian origin with review of the literature","volume":"118","author":"Daya D","year":"1994","journal-title":"Arch. Pathol. Lab. Med."},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.07.042"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/pgp.0b013e3180645136"},{"key":"e_1_2_11_58_1","first-page":"175","article-title":"Malignant female adnexal tumor of probable Wolffian origin: a case report","volume":"56","author":"Heller DS","year":"2011","journal-title":"J. Reprod. Med."},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2014.07.001"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000222"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2016.59.4.328"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000368"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2021.100838"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31820a406c"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001403"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2015.103"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197605)37:5<2349::AID-CNCR2820370526>3.0.CO;2-X"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810801)48:3<860::AID-CNCR2820480333>3.0.CO;2-I"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.5858\/2000-124-0431-MFATOP"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2002.6739"},{"key":"e_1_2_11_71_1","first-page":"189","article-title":"Female adnexal tumor of Wolffian origin","volume":"116","author":"Prasad CJ","year":"1992","journal-title":"Arch. Pathol. Lab. Med."},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1048-891x.2004.014319.x"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.5858\/2004-128-1301-PQCAYW"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02035.x"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2006.00364.x"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-009-1024-1"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e318203bc77"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3182005340"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.5874"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000422"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2016.12.017"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000656"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2021.100726"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000025377"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1996.0338"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199512000-00001"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198209000-00003"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821001)50:7<1322::AID-CNCR2820500718>3.0.CO;2-C"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31817c1b0a"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199704000-00017"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000350"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198508000-00001"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000149692.21205.9c"},{"key":"e_1_2_11_94_1","first-page":"656","article-title":"Inhibin expression in ovarian tumors and tumor\u2010like lesions: an immunohistochemical study","volume":"11","author":"Kommoss F","year":"1998","journal-title":"Mod. Pathol."},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318188373d"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0352-3"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr.2019.11.29"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012-0214-OA"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001766"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000444"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000573"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-020-01012-z"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11050827"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24675"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000023450"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2021.100856"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000027174"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2020.100652"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000541"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.4"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3181804bc6"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2009.09.010"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000301"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001016"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001165"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.107"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.06.018"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181ff400e"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2019.01.009"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000436"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000155"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000602"},{"key":"e_1_2_11_123_1","first-page":"317","article-title":"Mesonephric carcinoma of the ovary: a report of two cases","volume":"6","author":"Moerman P","year":"2015","journal-title":"J Cytol Histol"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896916644784"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-014-0193-9"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.645156"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.14662","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/his.14662","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.14662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T17:56:18Z","timestamp":1692726978000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.14662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,18]]},"references-count":125,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/his.14662"],"URL":"https:\/\/doi.org\/10.1111\/his.14662","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,18]]},"assertion":[{"value":"2022-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}