{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:52:30Z","timestamp":1791589950331,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T00:00:00Z","timestamp":1655078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      First described in 2014, renal cell carcinoma (RCC) with\n                      <jats:italic>TFEB<\/jats:italic>\n                      amplification (6p21) is a rare molecular subgroup whose diagnosis is challenging. The prognosis and therapeutic implications remain unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We report here the clinical, histological, immunohistochemical, and genetic features of nine novel cases. The pathological and immunohistochemical features were centrally reviewed by expert uropathologists. Fluorescence in\u2009situ hybridisation (FISH) confirmed the diagnosis and comparative genomic hybridisation (CGH) was performed to determine quantitative genomic alterations. We also performed an exhaustive review of the literature and compiled our data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>TFEB<\/jats:italic>\n                      \u2010amplified RCC were locally advanced, with initial lymph node involvement in one case and liver metastasis in another case. They were high\u2010grade eosinophilic tumours with papillary\/pseudopapillary architecture, frequent positivity for melanocytic markers, and frequent PDL1 expression. FISH demonstrated high\u2010level\n                      <jats:italic>TFEB<\/jats:italic>\n                      amplification in six cases. One case showed concomitant\n                      <jats:italic>TFEB<\/jats:italic>\n                      translocation. CGH analysis identified complex alterations with frequent losses of 1p, 2q, 3p, 6p, and frequent 6p and 8q gains.\n                      <jats:italic>VEGFA<\/jats:italic>\n                      coamplification was identified in all cases with a lower level than TFEB. The prognosis was poor, with five patients having lymph node or distant metastases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>TFEB<\/jats:italic>\n                      \u2010amplified RCC is a rare molecular subgroup with variable morphology whose diagnosis is confirmed by FISH analysis. The complex alterations identified by CGH are consistent with an aggressive clinical behaviour. The coamplification of\n                      <jats:italic>VEGFA<\/jats:italic>\n                      and the expression of PDL1 could suggest a potential benefit from antiangiogenics and targeted immunotherapy in combination for these aggressive tumours.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.14683","type":"journal-article","created":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T00:43:57Z","timestamp":1652489037000},"page":"228-238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Comprehensive study of nine novel cases of\n                    <scp>\n                      <i>TFEB<\/i>\n                    <\/scp>\n                    \u2010amplified renal cell carcinoma: an aggressive tumour with frequent\n                    <scp>PDL1<\/scp>\n                    expression"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6623-741X","authenticated-orcid":false,"given":"Sol\u00e8ne\u2010Florence","family":"Kammerer\u2010Jacquet","sequence":"first","affiliation":[{"name":"Department of Pathology University Hospital  Rennes France"},{"name":"UMR 6290\u2010IGDR  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Gandon","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Dugay","sequence":"additional","affiliation":[{"name":"UMR 6290\u2010IGDR  Rennes France"},{"name":"Department of Cytogenetics University Hospital  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Laguerre","sequence":"additional","affiliation":[{"name":"Department of Oncology Eug\u00e8ne Marquis Centre  Rennes 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Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Aubert","sequence":"additional","affiliation":[{"name":"University of Lille, CHU Lille Department of Pathology  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Vermaut","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University Hospital  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Escande","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University Hospital  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Verkarre","sequence":"additional","affiliation":[{"name":"Department of Pathology HEGP, AP\u2010HP\u2010centre, Paris University  Paris 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