{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T03:44:51Z","timestamp":1785469491409,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To improve understanding of the pathology of immune check\u2010point inhibitor (ICI)\u2010related pneumonitis, clinical, radiographic and histopathological features and outcomes were investigated in a cohort of patients who were treatment\u2010naive before receiving ICI inhibition, who underwent lung biopsy, and in whom other potential causes of lung injury were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were retrospectively identified via searches of institutional pathology and clinical records. Patients treated with other modalities for cancer and patients with lung infections or other aetiologies that could cause pneumonitis were excluded. Clinical records were reviewed by pulmonologists. Imaging studies at presentation and follow\u2010up were reviewed by a thoracic radiologist. Pathology was reviewed by thoracic pathologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six patients with ICI\u2010related pneumonitis were identified. Two patients presented with respiratory failure requiring mechanical ventilation, diffuse ground glass opacities (GGOs) on chest computed tomography (CT) and acute lung injury (ALI) pattern on transbronchial lung biopsies and had fatal outcomes, despite treatment. The remaining four patients presented with less severe symptoms, predominantly consolidations and patchy ground glass and part solid opacities on chest CT, organising pneumonia (OP) or chronic interstitial inflammation histologically, and showed favourable responses to treatment and remission within months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study highlights two radiological\u2013pathological patterns of ICI\u2010related pneumonitis with different behaviour: (1) severe respiratory symptoms and diffuse GGOs on imaging correlating with ALI pattern histologically and poor prognosis; and (2) mild respiratory symptoms and consolidations or patchy subsolid opacities on imaging correlating histologically with OP or chronic interstitial inflammation and good outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14704","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T12:58:06Z","timestamp":1656680286000},"page":"724-731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Immune check\u2010point inhibitor\u2010related pneumonitis: acute lung injury with rapid progression and organising pneumonia with less severe clinical disease"],"prefix":"10.1111","volume":"81","author":[{"given":"Saira","family":"Imran","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Golden","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D","family":"Travis","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane E","family":"Stover","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L","family":"Sauter","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY 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immune\u2010related events (DIRE) after discontinuation of immunotherapy: diagnostic hazard of autoimmunity at a distance","volume":"7","author":"Couey MA","year":"2019","journal-title":"J. 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